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DOI | 10.1152/physiol.00029.2014 |
Translating Animal Model Research: Does It Matter That Our Rodents Are Cold? | |
Maloney, Shane K.1,2; Fuller, Andrea2; Mitchell, Duncan1,2; Gordon, Christopher3; Overton, J. Michael4 | |
发表日期 | 2014-11-01 |
ISSN | 1548-9213 |
卷号 | 29期号:6页码:413-420 |
英文摘要 | Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality. |
语种 | 英语 |
WOS记录号 | WOS:000344996000006 |
来源期刊 | PHYSIOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60709 |
作者单位 | 1.Univ Western Australia, Sch Anat Physiol & Human Biol, Crawley, WA, Australia; 2.Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, Parktown, South Africa; 3.US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA; 4.Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA |
推荐引用方式 GB/T 7714 | Maloney, Shane K.,Fuller, Andrea,Mitchell, Duncan,et al. Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?[J]. 美国环保署,2014,29(6):413-420. |
APA | Maloney, Shane K.,Fuller, Andrea,Mitchell, Duncan,Gordon, Christopher,&Overton, J. Michael.(2014).Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?.PHYSIOLOGY,29(6),413-420. |
MLA | Maloney, Shane K.,et al."Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?".PHYSIOLOGY 29.6(2014):413-420. |
条目包含的文件 | 条目无相关文件。 |
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