CCPortal
DOI10.1186/s12989-014-0036-6
Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats
Upadhyay, Swapna1,2; Stoeger, Tobias1; George, Leema3; Schladweiler, Mette C.4; Kodavanti, Urmila4; Ganguly, Koustav1,3; Schulz, Holger1,5
发表日期2014-09-17
ISSN1743-8977
卷号11
英文摘要

Background: Studies provide compelling evidences for particulate matter (PM) associated cardiovascular health effects. Elderly individuals, particularly those with preexisting conditions like hypertension are regarded to be vulnerable. Experimental data are warranted to reveal the molecular pathomechanism of PM related cardiovascular impairments among aged/predisposed individuals. Thus we investigated the cardiovascular effects of ultrafine carbon particles (UfCP) on aged (12-13 months) spontaneously hypertensive rats (SHRs) and compared the findings with our pervious study on adult SHRs (6-7 months) to identify age related predisposition events in cardiovascular compromised elderly individuals.


Methods: Aged SHRs were inhalation exposed to UfCP for 24 h (similar to 180 mu g/m(3)) followed by radio-telemetric assessment for blood pressure (BP) and heart rate (HR). Bronchoalveolar lavage (BAL) fluid cell differentials, interleukin 6 (IL-6) and other proinflammatory cytokines; serum C-reactive protein (CRP) and haptoglobin (HPT); and plasma fibrinogen were measured. Transcript levels of hemeoxygenase 1 (HO-1), endothelin 1 (ET1), endothelin receptors A, B (ETA, ETB), tissue factor (TF), and plasminogen activator inhibitor-1 (PAI-1) were measured in the lung and heart to assess oxidative stress, endothelial dysfunction and coagulation cascade.


Result: UfCP exposed aged SHRs exhibited increased BP (4.4%) and HR (6.3%) on 1st recovery day paralleled by a 58% increase of neutrophils and 25% increase of IL-6 in the BAL fluid. Simultaneously higher CRP, HPT and fibrinogen levels in exposed SHRs indicate systemic inflammation. HO-1, ET1, ET-A, ET-B, TF and PAI-1 were induced by 1.5-2.0 folds in lungs of aged SHRs on 1st recovery day. However, in UfCP exposed adult SHRs these markers were up-regulated (2.5-6 fold) on 3rd recovery day in lung without detectable pulmonary/systemic inflammation.


Conclusions: The UfCP induced pulmonary and systemic inflammation in aged SHRs is associated with oxidative stress, endothelial dysfunction and disturbed coagulatory hemostasis. UfCP exposure increased BP and HR in aged SHRs rats which was associated with lung inflammation, and increased expression of inflammatory, vasoconstriction and coagulation markers as well as systemic changes in biomarkers of thrombosis in aged SHRs. Our study provides further evidence for potential molecular mechanisms explaining the increased risk of particle mediated cardiac health effects in cardiovascular compromised elderly individuals.


英文关键词Inflammation;Lung;Heart;Dust;Particle exposure;Cardiovascular risk individuals
语种英语
WOS记录号WOS:000345867800001
来源期刊PARTICLE AND FIBRE TOXICOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/60708
作者单位1.German Res Ctr Environm Hlth, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, Helmholtz Zentrum Munchen, Munich, Germany;
2.Indian Inst Technol, Dept Biotechnol, Madras 600036, Tamil Nadu, India;
3.SRM Univ, SRM Res Inst, Madras 603203, Tamil Nadu, India;
4.US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA;
5.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, D-85764 Neuherberg, Germany
推荐引用方式
GB/T 7714
Upadhyay, Swapna,Stoeger, Tobias,George, Leema,et al. Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats[J]. 美国环保署,2014,11.
APA Upadhyay, Swapna.,Stoeger, Tobias.,George, Leema.,Schladweiler, Mette C..,Kodavanti, Urmila.,...&Schulz, Holger.(2014).Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats.PARTICLE AND FIBRE TOXICOLOGY,11.
MLA Upadhyay, Swapna,et al."Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats".PARTICLE AND FIBRE TOXICOLOGY 11(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Upadhyay, Swapna]的文章
[Stoeger, Tobias]的文章
[George, Leema]的文章
百度学术
百度学术中相似的文章
[Upadhyay, Swapna]的文章
[Stoeger, Tobias]的文章
[George, Leema]的文章
必应学术
必应学术中相似的文章
[Upadhyay, Swapna]的文章
[Stoeger, Tobias]的文章
[George, Leema]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。