Climate Change Data Portal
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration | |
Cheng, Yating1; Jutooru, Indira1,4; Chadalapaka, Gayathri1; Corton, J. Christopher3; Safe, Stephen1,2 | |
发表日期 | 2015-05-10 |
ISSN | 1949-2553 |
卷号 | 6期号:13页码:10840-10852 |
英文摘要 | HOTTIP is a long non-coding RNA (lncRNA) transcribed from the 5' tip of the HOXA locus and is associated with the polycomb repressor complex 2 (PRC2) and WD repeat containing protein 5 (WDR5)/mixed lineage leukemia 1 (MLL1) chromatin modifying complexes. HOTTIP is expressed in pancreatic cancer cell lines and knockdown of HOTTIP by RNA interference (siHOTTIP) in Panc1 pancreatic cancer cells decreased proliferation, induced apoptosis and decreased migration. In Panc1 cells transfected with siHOTTIP, there was a decrease in expression of 757 genes and increased expression of 514 genes, and a limited gene analysis indicated that HOTTIP regulation of genes is complex. For example, Aurora kinase A, an important regulator of cell growth, is coregulated by MLL and not WDR5 and, in contrast to previous studies in liver cancer cells, HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1. Although HOTTIP and the HOX-associated lncRNA HOTAIR have similar pro-oncogenic functions, they regulate strikingly different sets of genes in Panc1 cells and in pancreatic tumors. |
英文关键词 | HOTTIP;lncRNA;HOX genes;pro-oncogenic;HOTAIR |
语种 | 英语 |
WOS记录号 | WOS:000359006400015 |
来源期刊 | ONCOTARGET |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60477 |
作者单位 | 1.Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA; 2.Texas A&M Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX 77030 USA; 3.US EPA, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA; 4.Covance Inc, Madison, WI 53704 USA |
推荐引用方式 GB/T 7714 | Cheng, Yating,Jutooru, Indira,Chadalapaka, Gayathri,et al. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration[J]. 美国环保署,2015,6(13):10840-10852. |
APA | Cheng, Yating,Jutooru, Indira,Chadalapaka, Gayathri,Corton, J. Christopher,&Safe, Stephen.(2015).The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.ONCOTARGET,6(13),10840-10852. |
MLA | Cheng, Yating,et al."The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration".ONCOTARGET 6.13(2015):10840-10852. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。