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DOI | 10.1016/j.envres.2014.03.020 |
Persistent organochlorines and hypertensive disorders of pregnancy | |
Savitz, David A.1; Klebanoff, Mark A.2,3; Wellenius, Gregory A.1; Jensen, Elizabeth T.4; Longnecker, Matthew P.4 | |
发表日期 | 2014-07-01 |
ISSN | 0013-9351 |
卷号 | 132页码:1-5 |
英文摘要 | Although there is indirect evidence to suggest that persistent organochlorines might increase risk of hypertensive disorders of pregnancy, there are no epidemiologic studies directly addressing this question. In this cohort study, sampled from the Collaborative Perinatal Project, 1933 women had complete data on organochlorine measurements, covariates, and pregnancy outcomes. Exposures to organochlorines were divided into quintiles, and levels were much higher in these patients recruited from 1959 to 1965 compared to levels in the general population at present. Among included women, 364 developed gestational hypertension (hypertension without proteinuria) and 131 developed preeclampsia (hypertension with proteinuria). We found essentially no association between serum DDE and total PCBs and risk of either gestational hypertension or preeclampsia. Results for other organochlorines showed varying patterns of results: DDT was inversely associated with risk of gestational hypertension (p for trend <0.001), B-Hexachlorocyclohexane and heptachlor epoxide were inversely related to gestational hypertension (p trend <0.01 and 0.10, respectively), dieldrin had a modestly positive association with gestational hypertension (p for trend = 0.12), and hexachlorobenzene, trans-nonachlor, and oxychlordane yielded results close to the null. Hexachlorobenzene showed an inverse association with preeclampsia (p for trend <0.001). The study suggests that persistent organochlorines present at historically high level are not likely to increase the risk of hypertensive disorders of pregnancy, suggesting that other toxicants that have similar biologic effects are also unlikely to do so. (C) 2014 Elsevier Inc. All rights reserved. |
英文关键词 | Organochlorines;PCBs;DDT;Gestational hypertension;Preeclampsia |
语种 | 英语 |
WOS记录号 | WOS:000337862300001 |
来源期刊 | ENVIRONMENTAL RESEARCH
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60247 |
作者单位 | 1.Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA; 2.Ohio State Univ, Coll Med, Nationwide Childrens Hosp, Dept Pediat, Columbus, OH 43210 USA; 3.Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA; 4.Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA |
推荐引用方式 GB/T 7714 | Savitz, David A.,Klebanoff, Mark A.,Wellenius, Gregory A.,et al. Persistent organochlorines and hypertensive disorders of pregnancy[J]. 美国环保署,2014,132:1-5. |
APA | Savitz, David A.,Klebanoff, Mark A.,Wellenius, Gregory A.,Jensen, Elizabeth T.,&Longnecker, Matthew P..(2014).Persistent organochlorines and hypertensive disorders of pregnancy.ENVIRONMENTAL RESEARCH,132,1-5. |
MLA | Savitz, David A.,et al."Persistent organochlorines and hypertensive disorders of pregnancy".ENVIRONMENTAL RESEARCH 132(2014):1-5. |
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