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DOI | 10.1016/j.freeradbiomed.2013.05.048 |
Zinc ions as effectors of environmental oxidative lung injury | |
Wu, Weidong1,2; Bromberg, Philip A.2; Samet, James M.3 | |
发表日期 | 2013-12-01 |
ISSN | 0891-5849 |
卷号 | 65页码:57-69 |
英文摘要 | The redox-inert transition metal Zn is a micronutrient that plays essential roles in protein structure, catalysis, and regulation of function. Inhalational exposure to ZnO or to soluble Zn salts in occupational and environmental settings leads to adverse health effects, the severity of which appears dependent on the flux of Zn2+ presented to the airway and alveolar cells. The cellular toxicity of exogenous Zn2+ exposure is chazracterized by cellular responses that include mitochondrial dysfunction, elevated production of reactive oxygen species, and loss of signaling quiescence leading to cell death and increased expression of adaptive and inflammatory genes. Central to the molecular effects of Zn2+ are its interactions with cysteinyl thiols, which alters their functionality by modulating their reactivity and participation in redox reactions. Ongoing studies aimed at elucidating the molecular toxicology of Zn2+ in the lung are contributing valuable information about its role in redox biology and cellular homeostasis in normal and pathophysiology. Published by Elsevier Inc. |
英文关键词 | Lung injury;Oxidant stress;Air pollution;Zinc;Reactive oxygen species;Metals |
语种 | 英语 |
WOS记录号 | WOS:000328868900006 |
来源期刊 | FREE RADICAL BIOLOGY AND MEDICINE |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60163 |
作者单位 | 1.XinXiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China; 2.Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA; 3.US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Chapel Hill, NC 27514 USA |
推荐引用方式 GB/T 7714 | Wu, Weidong,Bromberg, Philip A.,Samet, James M.. Zinc ions as effectors of environmental oxidative lung injury[J]. 美国环保署,2013,65:57-69. |
APA | Wu, Weidong,Bromberg, Philip A.,&Samet, James M..(2013).Zinc ions as effectors of environmental oxidative lung injury.FREE RADICAL BIOLOGY AND MEDICINE,65,57-69. |
MLA | Wu, Weidong,et al."Zinc ions as effectors of environmental oxidative lung injury".FREE RADICAL BIOLOGY AND MEDICINE 65(2013):57-69. |
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