气候变化领域集成服务门户(CCPortal): The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure

CCPortal

DOI	10.1016/j.reprotox.2014.12.002
	The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure
	Tucker, Deirdre K.1,2; Macon, Madisa B.1,2; Strynar, Mark J.3; Dagnino, Sonia 4; Andersen, Erik 5; Fenton, Suzanne E.2
发表日期	2015-07-01
ISSN	0890-6238
卷号	54 页码:26-36
英文摘要	Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (<= 1 mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain. Published by Elsevier Inc.
英文关键词	Perfluorooctanoic acid;Mammary gland;Puberty;CD-1;C57Bl/6;Vaginal opening;Estrous cycle
语种	英语
WOS记录号	WOS:000356401300005
来源期刊	REPRODUCTIVE TOXICOLOGY
来源机构	美国环保署
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/60139
作者单位	1.Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC 27599 USA; 2.NIEHS, Natl Toxicol Program Lab, Div NTP, NIH, Res Triangle Pk, NC 27709 USA; 3.US EPA, Methods Dev & Applicat Branch, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA; 4.US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA; 5.US EPA, Exposure Measurements & Anal Branch, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA
推荐引用方式 GB/T 7714	Tucker, Deirdre K.,Macon, Madisa B.,Strynar, Mark J.,et al. The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure[J]. 美国环保署,2015,54:26-36.
APA	Tucker, Deirdre K.,Macon, Madisa B.,Strynar, Mark J.,Dagnino, Sonia,Andersen, Erik,&Fenton, Suzanne E..(2015).The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure.REPRODUCTIVE TOXICOLOGY,54,26-36.
MLA	Tucker, Deirdre K.,et al."The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure".REPRODUCTIVE TOXICOLOGY 54(2015):26-36.