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DOI | 10.1111/ene.12632 |
Association between diabetes and amyotrophic lateral sclerosis in Sweden | |
Mariosa, D.1; Kamel, F.2; Bellocco, R.1,3; Ye, W.1; Fang, F.1 | |
发表日期 | 2015-11-01 |
ISSN | 1351-5101 |
卷号 | 22期号:11页码:1436-1442 |
英文摘要 | Background and purposeEnergy metabolism is altered in patients with amyotrophic lateral sclerosis (ALS) but the role of diabetes is largely unknown. MethodsA population-based case-control study was conducted of 5108 ALS cases and 25540 individually matched population controls during 1991-2010. Information on ALS and pre-existing diabetes was retrieved from the Swedish Patient Register to explore the association of ALS with diabetes overall and with insulin-dependent or non-insulin-dependent diabetes specifically. Variation of the association by diabetes duration and age was also studied. ResultsIn total, 224 ALS cases (4.39%) and 1437 controls (5.63%) had diabetes before the index date, leading to an overall inverse association between diabetes and ALS risk [odds ratio (OR)0.79, 95% confidence interval (CI)0.68-0.91]. The association was strong for non-insulin-dependent diabetes (OR0.66, 95% CI0.53-0.81) but not for insulin-dependent diabetes (OR0.83, 95% CI0.60-1.15) and varied as a function of diabetes duration, with the strongest association observed around 6years after first ascertainment of diabetes. The association was age-specific; the inverse association was noted only amongst individuals aged 70 or older. In contrast, for younger individuals (<50years), pre-existing insulin-dependent diabetes was associated with a higher ALS risk (OR5.38, 95% CI1.87-15.51). ConclusionsOur study suggests that there is an association between diabetes and ALS, and highlights the importance of taking into account age, insulin dependence and diabetes duration. Future studies should explore whether the association is independent of body mass index. Click to view the accompanying paper in this issue. |
英文关键词 | amyotrophic lateral sclerosis;diabetes;epidemiology;insulin dependence;metabolic and endocrine disorders;motor neuron disease;neurological disorders;neuromuscular diseases;research methods |
语种 | 英语 |
WOS记录号 | WOS:000362673300004 |
来源期刊 | EUROPEAN JOURNAL OF NEUROLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60098 |
作者单位 | 1.Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden; 2.Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA; 3.Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy |
推荐引用方式 GB/T 7714 | Mariosa, D.,Kamel, F.,Bellocco, R.,et al. Association between diabetes and amyotrophic lateral sclerosis in Sweden[J]. 美国环保署,2015,22(11):1436-1442. |
APA | Mariosa, D.,Kamel, F.,Bellocco, R.,Ye, W.,&Fang, F..(2015).Association between diabetes and amyotrophic lateral sclerosis in Sweden.EUROPEAN JOURNAL OF NEUROLOGY,22(11),1436-1442. |
MLA | Mariosa, D.,et al."Association between diabetes and amyotrophic lateral sclerosis in Sweden".EUROPEAN JOURNAL OF NEUROLOGY 22.11(2015):1436-1442. |
条目包含的文件 | 条目无相关文件。 |
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