Climate Change Data Portal
DOI | 10.1016/j.yrtph.2017.10.019 |
Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme | |
Rasmussen, Kirsten1; Rauscher, Hubert1; Mech, Agnieszka1; Sintes, Juan Riego1; Gilliland, Douglas1; Gonzalez, Mar2; Kearns, Peter2; Moss, Kenneth3; Visser, Maaike4; Groenewold, Monique4; Bleeker, Eric A. J.4 | |
发表日期 | 2018-02-01 |
ISSN | 0273-2300 |
卷号 | 92页码:8-28 |
英文摘要 | Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physicochemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted. |
英文关键词 | Manufactured nanomaterials;Physico-chemical properties;Characterisation;OECD test guidelines;Working party on manufactured nanomaterials |
语种 | 英语 |
WOS记录号 | WOS:000425840000002 |
来源期刊 | REGULATORY TOXICOLOGY AND PHARMACOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/60081 |
作者单位 | 1.European Commiss, Joint Res Ctr, Via E Fermi 2749, I-21027 Ispra, VA, Italy; 2.OECD, Environm Directorate, F-75775 Paris 16, France; 3.US EPA, Off Pollut Prevent & Tox 7405M, 1200 Penn Ave NW, Washington, DC 20460 USA; 4.Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands |
推荐引用方式 GB/T 7714 | Rasmussen, Kirsten,Rauscher, Hubert,Mech, Agnieszka,et al. Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme[J]. 美国环保署,2018,92:8-28. |
APA | Rasmussen, Kirsten.,Rauscher, Hubert.,Mech, Agnieszka.,Sintes, Juan Riego.,Gilliland, Douglas.,...&Bleeker, Eric A. J..(2018).Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme.REGULATORY TOXICOLOGY AND PHARMACOLOGY,92,8-28. |
MLA | Rasmussen, Kirsten,et al."Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme".REGULATORY TOXICOLOGY AND PHARMACOLOGY 92(2018):8-28. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。