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DOI | 10.1038/jes.2013.46 |
Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring | |
Hammond, Davyda1; Croghan, Carry1; Shin, Hwashin2; Burnett, Richard2; Bard, Robert3; Brook, Robert D.3; Williams, Ron1 | |
发表日期 | 2014-07-01 |
ISSN | 1559-0631 |
卷号 | 24期号:4页码:337-345 |
英文摘要 | The US Environmental Protection Agency's (US EPA) Detroit Exposure and Aerosol Research Study (DEARS) has provided extensive data on human exposures to a wide variety of air pollutants and their impact on human health. Previous analyses in the DEARS revealed select cardiovascular (CV) health outcomes such as increase in heart rate (HR) associated with hourly based continuous personal fine particulate matter (PM2.5) exposures in this adult, non-smoking cohort. Examination of time activity diary (TAD), follow-up questionnaire (FQ) and the continuous PM2.5 personal monitoring data provided the means to more fully examine the impact of discreet human activity patterns on personal PM2.5 exposures and changes in CV outcomes. A total of 329 343 min-based PM2.5 personal measurements involving 50 participants indicated that 75% of these total events resulted in exposures <35 mu g/m(3). Cooking and car-related events accounted for nearly 10% of the hourly activities that were identified with observed peaks in personal PM2.5 exposures. In-residence cooking often resulted in some of the highest incidents of 1 min exposures (33.5-17.6,mu g/m(3)), with average peaks for such events in excess of 209,mu g/m(3). PM2.5 exposure data from hourly based personal exposure activities (for example cooking, cleaning and household products) were compared with daily CV data from the DEARS subject population. A total of 1300 hourly based lag risk estimates associated with changes in brachial artery diameter and flow-mediated dilatation (BAD and FMD, respectively), among others, were defined for this cohort. Findings indicate that environmental tobacco smoke (ETS) exposures resulted in significant HR changes between 3 and 7h following the event, and exposure to smells resulted in increases in BAD on the order of 0.2-0.7 mm/mu g/m(3). Results demonstrate that personal exposures may be associated with several biological responses, sometimes varying in degree and direction in relation to the extent of the exposure. |
英文关键词 | DEARS;exposure factors;cardiovascular health outcomes |
语种 | 英语 |
WOS记录号 | WOS:000337651800001 |
来源期刊 | JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/59698 |
作者单位 | 1.US EPA, Res Triangle Pk, NC 27711 USA; 2.Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0L2, Canada; 3.Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA |
推荐引用方式 GB/T 7714 | Hammond, Davyda,Croghan, Carry,Shin, Hwashin,et al. Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring[J]. 美国环保署,2014,24(4):337-345. |
APA | Hammond, Davyda.,Croghan, Carry.,Shin, Hwashin.,Burnett, Richard.,Bard, Robert.,...&Williams, Ron.(2014).Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring.JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,24(4),337-345. |
MLA | Hammond, Davyda,et al."Cardiovascular impacts and micro-environmental exposure factors associated with continuous personal PM2.5 monitoring".JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 24.4(2014):337-345. |
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