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DOI | 10.1016/j.bbagen.2016.03.030 |
Inflammatory cell signaling following exposures to particulate matter and ozone | |
Yan, Zhen1; Jin, Yuefei1; An, Zhen2,3; Liu, Yingying2,3; Samet, James M.4; Wu, Weidong2,3,5 | |
发表日期 | 2016-12-01 |
ISSN | 0304-4165 |
卷号 | 1860期号:12页码:2826-2834 |
英文摘要 | Background: Particulate matter (PM) and ozone (O-3) are two major ambient air pollutants. Epidemiological and toxicological studies have demonstrated exposure to these pollutants is associated with a variety of adverse health effects, including cardiovascular and respiratory disease, in which inflammation is believed to be a common and essential factor. Scope of review: This review mainly focuses on major inflammatory cell signaling pathways triggered by exposure to PM and O-3. The receptors covered in this review include the EGF receptor, toll like receptor, and NOD-like receptor. Intracellular signaling protein kinases depicted in this review are phosphatidylinositol 3-kinase and mitogen-activated protein kinases. Activation of antioxidant and inflammatory transcription factors such as NrF2 and NF kappa B induced by PM and O-3 is also discussed. Major conclusions: Exposure to PM or O-3 can activate cellular signaling networks including membrane receptors, intracellular kinases and phosphatases, and transcription factors that regulate inflammatory responses. While PM induced cell signaling is associated with resultant ROS, O-3-induced cell signaling implicates phosphates. Notably, the cellular signaling induced by PM and O-3 exposure varies with cell type and physiochemical properties of these pollutants. General significance: Cellular signaling plays a critical role in the regulation of inflammatory pathogenesis. Elucidation of cellular signaling pathways initiated by PM or O-3 cannot only help to uncover the mechanisms of air pollutant toxicity but also provide clues for development of interventional measures against air pollution-induced disorders. (C) 2016 Elsevier B.V. All rights reserved. |
英文关键词 | Particulate matter;O-3;Cell signaling;Inflammation |
语种 | 英语 |
WOS记录号 | WOS:000384866700007 |
来源期刊 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/59167 |
作者单位 | 1.Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan Province, Peoples R China; 2.Xinxiang Med Univ, Sch Publ Hlth, 601 Jinsui St, Xinxiang 453003, Henan Province, Peoples R China; 3.Xinxiang Med Univ, Xinxiang Key Lab Environm Effects & Intervent, Xinxiang 453003, Henan Province, Peoples R China; 4.US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27599 USA; 5.Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang 453003, Henan Province, Peoples R China |
推荐引用方式 GB/T 7714 | Yan, Zhen,Jin, Yuefei,An, Zhen,et al. Inflammatory cell signaling following exposures to particulate matter and ozone[J]. 美国环保署,2016,1860(12):2826-2834. |
APA | Yan, Zhen,Jin, Yuefei,An, Zhen,Liu, Yingying,Samet, James M.,&Wu, Weidong.(2016).Inflammatory cell signaling following exposures to particulate matter and ozone.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1860(12),2826-2834. |
MLA | Yan, Zhen,et al."Inflammatory cell signaling following exposures to particulate matter and ozone".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1860.12(2016):2826-2834. |
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