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DOI | 10.1016/j.mrrev.2014.04.001 |
Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview | |
Eastmond, David A.1; Keshava, Nagalakshmi2; Sonawane, Babasaheb2 | |
发表日期 | 2014-07-01 |
ISSN | 1383-5742 |
卷号 | 761页码:40-64 |
英文摘要 | Lymphohematopoietic neoplasia are one of the most common types of cancer induced by therapeutic and environmental agents. Of the more than 100 human carcinogens identified by the International Agency for Research on Cancer, approximately 25% induce leukemias or lymphomas. The objective of this review is to provide an introduction into the origins and mechanisms underlying lymphohematopoietic cancers induced by xenobiotics in humans with an emphasis on acute myeloid leukemia, and discuss the implications of this information for risk assessment. Among the agents causing lymphohematopoietic cancers, a number of patterns were observed. Most physical and chemical leukemia-inducing agents such as the therapeutic alkylating agents, topoisomerase II inhibitors, and ionizing radiation induce mainly acute myeloid leukemia through DNA-damaging mechanisms that result in either gene or chromosomal mutations. In contrast, biological agents and a few immunosuppressive chemicals induce primarily lymphoid neoplasms through mechanisms that involve alterations in immune response. Among the environmental agents examined, benzene was clearly associated with acute myeloid leukemia in humans, with increasing but still limited evidence for an association with lymphoid neoplasms. Ethylene oxide and 1,3-butadiene were linked primarily to lymphoid cancers. Although the association between formaldehyde and leukemia remains controversial, several recent evaluations have indicated a potential link between formaldehyde and acute myeloid leukemia. The four environmental agents examined in detail were all genotoxic, inducing gene mutations, chromosomal alterations, and/or micronuclei in vivo. Although it is clear that rapid progress has been made in recent years in our understanding of leukemogenesis, many questions remain for future research regarding chemically induced leukemias and lymphomas, including the mechanisms by which the environmental agents reviewed here induce these diseases and the risks associated with exposures to such agents. (C) 2014 Elsevier B.V. All rights reserved. |
英文关键词 | Leukemia;Neoplasia;Carcinogens;Environmental agents;Risk assessment |
语种 | 英语 |
WOS记录号 | WOS:000343360700005 |
来源期刊 | MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/58821 |
作者单位 | 1.Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA; 2.US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA |
推荐引用方式 GB/T 7714 | Eastmond, David A.,Keshava, Nagalakshmi,Sonawane, Babasaheb. Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview[J]. 美国环保署,2014,761:40-64. |
APA | Eastmond, David A.,Keshava, Nagalakshmi,&Sonawane, Babasaheb.(2014).Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview.MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH,761,40-64. |
MLA | Eastmond, David A.,et al."Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview".MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 761(2014):40-64. |
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