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DOI | 10.1016/j.taap.2014.08.010 |
A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices | |
Schlosser, Paul M.; Sasso, Alan F. | |
发表日期 | 2014-10-15 |
ISSN | 0041-008X |
卷号 | 280期号:2页码:352-361 |
英文摘要 | Chronic oral exposure to hexavalent chromium (Cr-VI) in drinking water has been shown to induce tumors in the mouse gastrointestinal (GI) tract and rat oral cavity. The same is not true for trivalent chromium (Cr-III). Thus reduction of Cr-VI to Cr-III in gastric juices is considered a protective mechanism, and it has been suggested that the difference between the rate of reduction among mice, rats, and humans could explain or predict differences in sensitivity to Cr-VI. We evaluated previously published models of gastric reduction and believe that they do not fully describe the data on reduction as a function of Cr-VI concentration, time, and (in humans) pH. The previous models are parsimonious in assuming only a single reducing agent in rodents and describing pH-dependence using a simple function. We present a revised model that assumes three pools of reducing agents in rats and mice with pH-dependence based on known speciation chemistry. While the revised model uses more fitted parameters than the original model, they are adequately identifiable given the available data, and the fit of the revised model to the full range of data is shown to be significantly improved. Hence the revised model should provide better predictions of Cr-VI reduction when integrated into a corresponding PBPK model. Published by Elsevier Inc. |
英文关键词 | Hexavalent chromium;Reduction;Gastric juice;Mouse;Rat;Human |
语种 | 英语 |
WOS记录号 | WOS:000344444700017 |
来源期刊 | TOXICOLOGY AND APPLIED PHARMACOLOGY
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/58661 |
作者单位 | US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA |
推荐引用方式 GB/T 7714 | Schlosser, Paul M.,Sasso, Alan F.. A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices[J]. 美国环保署,2014,280(2):352-361. |
APA | Schlosser, Paul M.,&Sasso, Alan F..(2014).A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices.TOXICOLOGY AND APPLIED PHARMACOLOGY,280(2),352-361. |
MLA | Schlosser, Paul M.,et al."A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices".TOXICOLOGY AND APPLIED PHARMACOLOGY 280.2(2014):352-361. |
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