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DOI | 10.1093/toxsci/kfv331 |
Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats | |
Miller, Desinia B.1; Snow, Samantha J.2; Schladweiler, Mette C.2; Richards, Judy E.2; Ghio, Andrew J.2; Ledbetter, Allen D.2; Kodavanti, Urmila P.2 | |
发表日期 | 2016-04-01 |
ISSN | 1096-6080 |
卷号 | 150期号:2页码:312-322 |
英文摘要 | Acute ozone exposure increases circulating stress hormones and induces metabolic alterations in animals. We hypothesized that the increase of adrenal-derived stress hormones is necessary for both ozone-induced metabolic effects and lung injury. Male Wistar-Kyoto rats underwent bilateral adrenal demedullation (DEMED), total bilateral adrenalectomy (ADREX), or sham surgery (SHAM). After a 4 day recovery, rats were exposed to air or ozone (1 ppm), 4 h/day for 1 or 2 days and responses assessed immediately postexposure. Circulating adrenaline levels dropped to nearly zero in DEMED and ADREX rats relative to SHAM. Corticosterone tended to be low in DEMED rats and dropped to nearly zero in ADREX rats. Adrenalectomy in air-exposed rats caused modest changes in metabolites and lung toxicity parameters. Ozone-induced hyperglycemia and glucose intolerance were markedly attenuated in DEMED rats with nearly complete reversal in ADREX rats. Ozone increased circulating epinephrine and corticosterone in SHAM but not in DEMED or ADREX rats. Free fatty acids (P = .15) and branched-chain amino acids increased after ozone exposure in SHAM but not in DEMED or ADREX rats. Lung minute volume was not affected by surgery or ozone but ozone-induced labored breathing was less pronounced in ADREX rats. Ozone-induced increases in lung protein leakage and neutrophilic inflammation were markedly reduced in DEMED and ADREX rats (ADREX > DEMED). Ozone-mediated decreases in circulating white blood cells in SHAM were not observed in DEMED and ADREX rats. We demonstrate that ozone-induced peripheral metabolic effects and lung injury/inflammation are mediated through adrenal-derived stress hormones likely via the activation of stress response pathway. |
英文关键词 | ozone;adrenalectomy;stress response;HPA-axis;lung injury |
语种 | 英语 |
WOS记录号 | WOS:000374230300007 |
来源期刊 | TOXICOLOGICAL SCIENCES
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/58568 |
作者单位 | 1.Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA; 2.US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Miller, Desinia B.,Snow, Samantha J.,Schladweiler, Mette C.,et al. Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats[J]. 美国环保署,2016,150(2):312-322. |
APA | Miller, Desinia B..,Snow, Samantha J..,Schladweiler, Mette C..,Richards, Judy E..,Ghio, Andrew J..,...&Kodavanti, Urmila P..(2016).Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats.TOXICOLOGICAL SCIENCES,150(2),312-322. |
MLA | Miller, Desinia B.,et al."Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats".TOXICOLOGICAL SCIENCES 150.2(2016):312-322. |
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