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DOI10.1289/EHP1265
A Method for Identifying Prevalent Chemical Combinations in the US Population
Kapraun, Dustin F.1; Wambaugh, John F.1; Ring, Caroline L.1,2; Tornero-Velez, Rogelio3; Setzer, R. Woodrow1
发表日期2017-08-01
ISSN0091-6765
卷号125期号:8
英文摘要

BACKGROUND: Through the food and water they ingest, the air they breathe, and the consumer products with which they interact al home and at work, humans are exposed to tens of thousands of chemicals, many of which have not been evaluated to determine their potential toxicities. Furthermore, while current chemical testing tends to focus on individual chemicals, the exposures that people actually experience involve mixtures of chemicals. Unfortunately, the number of mixtures that can be formed from the thousands of environmental chemicals is enormous, and testing all of them would be impossible.


OBJECTIVES: We seek to develop and demonstrate a method for identifying those mixtures that are most prevalent in humans.


METHODS: We applied frequent itemset mining, a technique traditionally used for market basket analysis, to biomonitoring data from the 2009-2010 cycle of the continuous National Health and Nutrition Examination Survey (NHANES) to identify combinations of chemicals that frequently co-occur in people.


RESULTS: We identified 90 chemical combinations consisting of relatively few chemicals that occur in at least 30% of the U.S. population, as well as three supercombinations consisting of relatively many chemicals that occur in a small but nonnegligible proportion of the U.S. population.


CONCLUSIONS: We demonstrated how FIM can be used in conjunction with biomonitoring data to narrow a large number of possible chemical combinations down to a smaller set of prevalent chemical combinations.


语种英语
WOS记录号WOS:000413790600027
来源期刊ENVIRONMENTAL HEALTH PERSPECTIVES
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/58400
作者单位1.US EPA, Natl Ctr Computat Toxicol, Mail Drop D143-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA;
2.Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA;
3.US EPA, Natl Exposure Res Lab, Mail Drop D143-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA
推荐引用方式
GB/T 7714
Kapraun, Dustin F.,Wambaugh, John F.,Ring, Caroline L.,et al. A Method for Identifying Prevalent Chemical Combinations in the US Population[J]. 美国环保署,2017,125(8).
APA Kapraun, Dustin F.,Wambaugh, John F.,Ring, Caroline L.,Tornero-Velez, Rogelio,&Setzer, R. Woodrow.(2017).A Method for Identifying Prevalent Chemical Combinations in the US Population.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8).
MLA Kapraun, Dustin F.,et al."A Method for Identifying Prevalent Chemical Combinations in the US Population".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017).
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