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DOI | 10.1289/EHP1265 |
A Method for Identifying Prevalent Chemical Combinations in the US Population | |
Kapraun, Dustin F.1; Wambaugh, John F.1; Ring, Caroline L.1,2; Tornero-Velez, Rogelio3; Setzer, R. Woodrow1 | |
发表日期 | 2017-08-01 |
ISSN | 0091-6765 |
卷号 | 125期号:8 |
英文摘要 | BACKGROUND: Through the food and water they ingest, the air they breathe, and the consumer products with which they interact al home and at work, humans are exposed to tens of thousands of chemicals, many of which have not been evaluated to determine their potential toxicities. Furthermore, while current chemical testing tends to focus on individual chemicals, the exposures that people actually experience involve mixtures of chemicals. Unfortunately, the number of mixtures that can be formed from the thousands of environmental chemicals is enormous, and testing all of them would be impossible. OBJECTIVES: We seek to develop and demonstrate a method for identifying those mixtures that are most prevalent in humans. METHODS: We applied frequent itemset mining, a technique traditionally used for market basket analysis, to biomonitoring data from the 2009-2010 cycle of the continuous National Health and Nutrition Examination Survey (NHANES) to identify combinations of chemicals that frequently co-occur in people. RESULTS: We identified 90 chemical combinations consisting of relatively few chemicals that occur in at least 30% of the U.S. population, as well as three supercombinations consisting of relatively many chemicals that occur in a small but nonnegligible proportion of the U.S. population. CONCLUSIONS: We demonstrated how FIM can be used in conjunction with biomonitoring data to narrow a large number of possible chemical combinations down to a smaller set of prevalent chemical combinations. |
语种 | 英语 |
WOS记录号 | WOS:000413790600027 |
来源期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/58400 |
作者单位 | 1.US EPA, Natl Ctr Computat Toxicol, Mail Drop D143-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA; 2.Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA; 3.US EPA, Natl Exposure Res Lab, Mail Drop D143-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Kapraun, Dustin F.,Wambaugh, John F.,Ring, Caroline L.,et al. A Method for Identifying Prevalent Chemical Combinations in the US Population[J]. 美国环保署,2017,125(8). |
APA | Kapraun, Dustin F.,Wambaugh, John F.,Ring, Caroline L.,Tornero-Velez, Rogelio,&Setzer, R. Woodrow.(2017).A Method for Identifying Prevalent Chemical Combinations in the US Population.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Kapraun, Dustin F.,et al."A Method for Identifying Prevalent Chemical Combinations in the US Population".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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