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DOI | 10.1016/j.toxlet.2018.03.001 |
Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays | |
Farmer, W. T.1,2; Louis, G. W.1,2; Buckalew, A. R.1; Hallinger, D. R.1; Stoker, T. E.1 | |
发表日期 | 2018-07-01 |
ISSN | 0378-4274 |
卷号 | 291页码:194-199 |
英文摘要 | Triclosan (TCS) is an antibacterial widely used in personal care products that exhibits endocrine disrupting activity in several species, with reports of altered thyroid, estrogen and androgen signaling pathways. To evaluate the androgenic mode of action, TCS was evaluated for androgen receptor mediated effects in the Hershberger assay and for altered androgen synthesis in the H295R steroidogenesis assay. In the Hershberger assay, castrated males were dosed by oral gavage for 10 days with corn oil (vehicle) or TCS (50 or 200 mg/kg/day) in the presence or absence of testosterone proprionate (TP, 0.2 mg/kg/day) prior to assessing accessory sex tissues (ASTs) weights. TCS alone or in combination with TP did not alter androgen dependent AST weights. Assessment of serum thyroxine (T4) demonstrated a significant dose-dependent decrease by TCS (50 or 200 mg/kg/day) co-administered with TP and TCS (200 mg/kg) without TP, but no differences in liver or thyroid weights. In the H295R assay, TCS from 0.01 to 10 mu M had no effect on testosterone production but TCS at 3 mu M and above did induce a significant increase in estrogen production. At 10 mu M, TCS produced significant cytotoxicity which confounded the interpretation of the estrogenic effect at that concentration. Thus, TCS had no effect on androgen synthesis or activity in the models used, but did enhance estrogen production and suppress serum T4. |
英文关键词 | Triclosan;Hershberger;H295R;Steroidogenesis;Endocrine disruptor |
语种 | 英语 |
WOS记录号 | WOS:000432602600020 |
来源期刊 | TOXICOLOGY LETTERS
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/58317 |
作者单位 | 1.US EPA, Endocrine Toxicol Branch, Toxic Assessment Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA; 2.US DOE, Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA |
推荐引用方式 GB/T 7714 | Farmer, W. T.,Louis, G. W.,Buckalew, A. R.,et al. Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays[J]. 美国环保署,2018,291:194-199. |
APA | Farmer, W. T.,Louis, G. W.,Buckalew, A. R.,Hallinger, D. R.,&Stoker, T. E..(2018).Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays.TOXICOLOGY LETTERS,291,194-199. |
MLA | Farmer, W. T.,et al."Evaluation of triclosan in the Hershberger and H295R steroidogenesis assays".TOXICOLOGY LETTERS 291(2018):194-199. |
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