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DOI10.1016/j.fct.2016.07.025
Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model
Melnyk, Lisa Jo1; Wang, Zhaohui2,3; Li, Zhilin3; Xue, Jianping2
发表日期2016-10-01
ISSN0278-6915
卷号96页码:167-173
英文摘要

A major pathway for exposure to many pesticides is through diet. The objectives were to rank pesticides by comparing their calculated daily dietary exposure as determined by EPA's Stochastic Human Exposure and Dose Simulation (SHEDS) to single pesticides for different age groups to acceptable daily intakes (ADI), characterize pesticide trends in exposures over different time periods, and determine commodities contributing to pesticide exposures. SHEDS was applied, using Pesticide Data Program (PDP) (1991-2011) and pesticide usage data on crops from USDA combined with NHANES dietary consumption data, to generate exposure estimates by age group. ADI data collected from EPA, WHO, and other sources were used to rank pesticides based on relativeness of the dietary exposure potential to ADI by age groups. Sensitivity analysis provided trends in pesticide exposures. Within SHEDS, commodities contributing the majority of pesticides with greatest exposure potential were determined. The results indicated that the highest ranking pesticides were methamidophos and diazinon which exceeded 100% of the ADI. Sensitivity analysis indicated that exposure to methamidophos, diazinon, malathion, ethion and formetanate hydrochloride had a marked decrease from 1991-1999 to 2000-2011. Contributions analysis indicated that apples, mushroom, carrots, and lettuce contributed to diazinon exposure. Beans and pepper contributed to methamidophos exposure. Published by Elsevier Ltd.


英文关键词Risk ranking;Pesticides;Dietary exposure;ADI
语种英语
WOS记录号WOS:000383825300018
来源期刊FOOD AND CHEMICAL TOXICOLOGY
来源机构美国环保署
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/58192
作者单位1.US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA;
2.US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA;
3.North Carolina State Univ, Dept Math, Box 8205, Raleigh, NC 27695 USA
推荐引用方式
GB/T 7714
Melnyk, Lisa Jo,Wang, Zhaohui,Li, Zhilin,et al. Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model[J]. 美国环保署,2016,96:167-173.
APA Melnyk, Lisa Jo,Wang, Zhaohui,Li, Zhilin,&Xue, Jianping.(2016).Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model.FOOD AND CHEMICAL TOXICOLOGY,96,167-173.
MLA Melnyk, Lisa Jo,et al."Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model".FOOD AND CHEMICAL TOXICOLOGY 96(2016):167-173.
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