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DOI | 10.1177/1535370217717697 |
Programming microphysiological systems for children's health protection | |
Knudsen, T. B.1; Klieforth, B.2; Slikker, W., Jr.3 | |
发表日期 | 2017-10-01 |
ISSN | 1535-3702 |
卷号 | 242期号:16页码:1586-1592 |
英文摘要 | Microphysiological systems (MPS) and computer simulation models that recapitulate the underlying biology and toxicology of critical developmental transitions are emerging tools for developmental effects assessment of drugs/chemicals. Opportunities and challenges exist for their application to alternative, more public health relevant and efficient chemical toxicity testing methods. This is especially pertinent to children's health research and the evaluation of complex embryological and reproductive impacts of drug/chemical exposure. Scaling these technologies to higher throughput is a key challenge and drives the need for in silico models for quantitative prediction of developmental toxicity to inform safety assessments. One example is cellular agent-based models, constructed from extant embryology, that produce data useful to simulate critical developmental transitions and thereby predict phenotypic consequences of disruption in silico. Biologically inspired MPS models built from human induced pluripotent stem (iPS)-derived cells and synthetic matrices that recapitulate organ-specific physiologies and native tissue architectures are providing exciting new research opportunities to advance the assessment of developmental toxicity and offer the possibility of deriving a full human on a chip' system, or a "Homunculus". |
英文关键词 | Developmental;toxicology;systems;computational;conceptus;organ |
语种 | 英语 |
WOS记录号 | WOS:000413732400004 |
来源期刊 | EXPERIMENTAL BIOLOGY AND MEDICINE |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/57936 |
作者单位 | 1.US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA; 2.US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA; 3.US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA |
推荐引用方式 GB/T 7714 | Knudsen, T. B.,Klieforth, B.,Slikker, W., Jr.. Programming microphysiological systems for children's health protection[J]. 美国环保署,2017,242(16):1586-1592. |
APA | Knudsen, T. B.,Klieforth, B.,&Slikker, W., Jr..(2017).Programming microphysiological systems for children's health protection.EXPERIMENTAL BIOLOGY AND MEDICINE,242(16),1586-1592. |
MLA | Knudsen, T. B.,et al."Programming microphysiological systems for children's health protection".EXPERIMENTAL BIOLOGY AND MEDICINE 242.16(2017):1586-1592. |
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