Climate Change Data Portal
DOI | 10.1615/JEnvironPatholToxicolOncol.2015013397 |
Iron and Iron-Related Proteins in Asbestosis | |
Ghio, Andrew J.; Pavlisko, Elizabeth N.; Roggli, Victor L. | |
发表日期 | 2015 |
ISSN | 0731-8898 |
卷号 | 34期号:4页码:277-285 |
英文摘要 | We tested the postulate that iron homeostasis is altered among patients diagnosed to have asbestosis. Lung tissue from six individuals diagnosed to have had asbestosis at autopsy was stained for iron, ferritin, divalent metal transporter 1 (DMT1), and ferroportin 1 (FPN1). Slides from six individuals having pneumonectomy for lung cancer were employed as controls. Lung tissue from those patients with asbestosis demonstrated stainable iron, whereas control lung tissue did not. Staining for this metal was observed predominantly in airway and alveolar macrophages. Expression of the iron-related proteins ferritin, DMT1, and FPN1 was elevated in lung tissue from the six asbestosis patients relative to controls. This increased expression of iron-transport and iron-storage proteins was evident in both airway and alveolar epithelial cells. Asbestos bodies were abundant in lung tissue from patients diagnosed to have had asbestosis. While staining for iron, ferruginous bodies did not demonstrate uptake of antibodies for ferritin. DMT1. and FPN1. We conclude that iron homeostasis is altered in lung disease among those diagnosed to have asbestosis with an accumulation of the metal and a modified expression of iron-related proteins being evident. |
英文关键词 | asbestos;asbestosis;iron;divalent metal transporter 1;ferritin;metal transport protein 1 |
语种 | 英语 |
WOS记录号 | WOS:000368384600001 |
来源期刊 | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
![]() |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/57773 |
作者单位 | (1)US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC 27711 USA;(2)Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA |
推荐引用方式 GB/T 7714 | Ghio, Andrew J.,Pavlisko, Elizabeth N.,Roggli, Victor L.. Iron and Iron-Related Proteins in Asbestosis[J]. 美国环保署,2015,34(4):277-285. |
APA | Ghio, Andrew J.,Pavlisko, Elizabeth N.,&Roggli, Victor L..(2015).Iron and Iron-Related Proteins in Asbestosis.JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY,34(4),277-285. |
MLA | Ghio, Andrew J.,et al."Iron and Iron-Related Proteins in Asbestosis".JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY 34.4(2015):277-285. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。