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DOI | 10.1016/j.neurobiolaging.2016.02.027 |
Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats | |
Pandya, Jignesh D.1; Royland, Joyce E.2; MacPhail, Robert C.3; Sullivan, Patrick G.1; Kodavanti, Prasada Rao S.3 | |
发表日期 | 2016-06-01 |
ISSN | 0197-4580 |
卷号 | 42页码:25-34 |
英文摘要 | Mitochondria are central regulators of energy homeostasis and play a pivotal role in mechanisms of cellular senescence. The objective of the present study was to evaluate mitochondrial bioenergetic parameters in 5 brain regions (brain stem [BS], frontal cortex, cerebellum, striatum, hippocampus [HIP]) of 4 diverse age groups (1 month [young], 4 months [adult], 12 months [middle-aged], 24 months [old age]) to understand age-related differences in selected brain regions and their possible contribution to age-related chemical sensitivity. Mitochondrial bioenergetic parameters and enzyme activities were measured under identical conditions across multiple age groups and brain regions in Brown Norway rats (n = 5/group). The results indicate age-and brain regionespecific patterns in mitochondrial functional endpoints. For example, an age-specific decline in ATP synthesis (State III respiration) was observed in BS and HIP. Similarly, the maximal respiratory capacities (State V-1 and V-2) showed age-specific declines in all brain regions examined (young > adult > middle-aged > old age). Amongst all regions, HIP had the greatest change in mitochondrial bioenergetics, showing declines in the 4, 12, and 24-months age groups. Activities of mitochondrial pyruvate dehydrogenase complex and electron transport chain complexes I, II, and IV enzymes were also age and brain region specific. In general, changes associated with age were more pronounced with enzyme activities declining as the animals aged (young > adult > middle-aged > old age). These age-and brain region-specific observations may aid in evaluating brain bioenergetic impact on the age-related susceptibility to environmental chemical stressors. Published by Elsevier Inc. |
英文关键词 | Aging;Bioenergetics;Enzyme activity;Mitochondria;Brain regions;Rats;Susceptibility |
语种 | 英语 |
WOS记录号 | WOS:000375129500003 |
来源期刊 | NEUROBIOLOGY OF AGING
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来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/57699 |
作者单位 | 1.Univ Kentucky, Dept Anat & Neurobiol, Spinal Cord & Brain Injury Res Ctr, Lexington, KY 40536 USA; 2.US EPA, Genet & Cellular Toxicol Branch, Integrated Syst Toxicol Div, NHEERL ORD, Res Triangle Pk, NC 27711 USA; 3.US EPA, Neurotoxicol Branch, Tox Assessment Div, NHEERL ORD, B105-04, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Pandya, Jignesh D.,Royland, Joyce E.,MacPhail, Robert C.,et al. Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats[J]. 美国环保署,2016,42:25-34. |
APA | Pandya, Jignesh D.,Royland, Joyce E.,MacPhail, Robert C.,Sullivan, Patrick G.,&Kodavanti, Prasada Rao S..(2016).Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats.NEUROBIOLOGY OF AGING,42,25-34. |
MLA | Pandya, Jignesh D.,et al."Age- and brain region-specific differences in mitochondrial bioenergetics in Brown Norway rats".NEUROBIOLOGY OF AGING 42(2016):25-34. |
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