Climate Change Data Portal
DOI | 10.1002/chir.22211 |
Enantiomer-Specific In Vitro Biotransformation of Select Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss) | |
Connors, Kristin A.1,2,3; Du, Bowen1,2,4; Fitzsimmons, Patrick N.5; Chambliss, C. Kevin2,4,6; Nichols, John W.5; Brooks, Bryan W.1,2,3,4 | |
发表日期 | 2013-11-01 |
ISSN | 0899-0042 |
卷号 | 25期号:11页码:763-767 |
英文摘要 | The occurrence of pharmaceuticals in the environment represents a challenge of emerging concern. Many pharmaceuticals are chiral compounds; however, few studies have examined the relative toxicity of pharmaceutical enantiomers to wildlife. Further, our understanding of stereospecific pharmacokinetics remains largely informed by research on humans and a few well-studied laboratory test animals, and not by studies conducted with environmentally relevant species, including fish. The objective of this study was to investigate whether rainbow trout display stereospecific in vitro metabolism of three common chiral pharmaceuticals. Metabolism by trout liver S9 fractions was evaluated using a substrate depletion approach, which provides an estimate of intrinsic hepatic clearance (CLIN VITRO,INT). No biotransformation was observed for rac-, R-, or S-fluoxetine. Ibuprofen, including both enantiomers and the racemic mixture, appeared to undergo slow metabolism, but the resulting substrate depletion curves did not differ significantly from those of inactive controls. Contrary to relative clearance rates in humans, S(-)-propranolol was more rapidly cleared than the R(+)- enantiomer. This work demonstrates that relative clearance rates and the effects of racemic mixtures in trout could not have been predicted based on human data. Additional research describing species differences and exploring tools for species extrapolation in biomedical and environmental studies is needed. Chirality 25:763-767, 2013, (c) 2013 Wiley Periodicals, Inc. |
英文关键词 | environmental risk assessment;bioaccumulation;contaminants of emerging concern;comparative pharmacokinetics;metabolic biotransformation |
语种 | 英语 |
WOS记录号 | WOS:000326291700013 |
来源期刊 | CHIRALITY |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/57556 |
作者单位 | 1.Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA; 2.Baylor Univ, Ctr Reservoir & Aquat Syst Res, Waco, TX 76798 USA; 3.Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA; 4.Baylor Univ, Inst Ecol Earth & Environm Sci, Waco, TX 76798 USA; 5.US EPA, Duluth, MN USA; 6.Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA |
推荐引用方式 GB/T 7714 | Connors, Kristin A.,Du, Bowen,Fitzsimmons, Patrick N.,et al. Enantiomer-Specific In Vitro Biotransformation of Select Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss)[J]. 美国环保署,2013,25(11):763-767. |
APA | Connors, Kristin A.,Du, Bowen,Fitzsimmons, Patrick N.,Chambliss, C. Kevin,Nichols, John W.,&Brooks, Bryan W..(2013).Enantiomer-Specific In Vitro Biotransformation of Select Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss).CHIRALITY,25(11),763-767. |
MLA | Connors, Kristin A.,et al."Enantiomer-Specific In Vitro Biotransformation of Select Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss)".CHIRALITY 25.11(2013):763-767. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。