气候变化领域集成服务门户

Diet-induced obesity has been suggested to lead to increased susceptibility to air pollutants such as ozone (O-3); however, there is little experimental evidence. Thirty day old male and female Brown Norway rats were fed a normal, high-fructose or high-fat diet for 12 weeks and then exposed to O-3 (acute - air or 0.8ppm O-3 for 5 h, or subacute - air or 0.8ppm O-3 for 5 h/d 1 d/week for 4 weeks). Body composition was measured non-invasively using NMR. Ventilatory parameters and exploratory behavior were measured after the third week of subacute exposure. Bronchoalveolar lavage fluid (BALF) and blood chemistry data were collected 18 h after acute O-3 and 18 h after the fourth week of subacute O-3. The diets led to increased body fat in male but not female rats. O-3-induced changes in ventilatory function were either unaffected or improved with the fructose and fat diets. O-3-induced reduction in exploratory behavior was attenuated with fructose and fat diets in males and partially in females. O-3 led to a significant decrease in body fat of males fed control diet but not the fructose or fat diet. O-3 led to significant increases in BALF eosinophils, increase in albumin, and reductions in macrophages. Female rats appeared to be more affected than males to O-3 regardless of diet. Overall, treatment with high-fructose and high-fat diets attenuated some O-3 induced effects on pulmonary function, behavior, and metabolism. Exacerbation of toxicity was observed less frequently.