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DOI | 10.1016/j.jmgm.2017.03.017 |
Predicted phototoxicities of carbon nano-material by quantum mechanical calculations | |
Betowski, Don | |
发表日期 | 2017-08-01 |
ISSN | 1093-3263 |
卷号 | 75页码:102-105 |
英文摘要 | The purpose of this research was to develop a predictive model for the phototoxicity potential of carbon nanomaterials (fullerenols and single-walled carbon nanotubes). This model is based on the quantum mechanical (ab initio) calculations on these carbon-based materials and comparison of the triplet excited states of these materials to published work relating phototoxicity of polynuclear aromatic hydrocarbons (PAH) to their predictive triplet excited state energy. A successful outcome will add another tool to the arsenal of predictive methods for the U.S. EPA program offices as they assess the toxicity of compounds in use or coming into commerce. The basis of this research was obtaining the best quantum mechanical structure of the carbon nano material and was fundamental in determining the triplet excited state energy. The triplet excited state, in turn, is associated with the phototoxicity of the material. This project relies heavily on the interaction of the predictive results (physical chemistry) and the experimental results obtained by biologists and toxicologists. The results of the experiments (toxicity testing) will help refine the predictive model, while the predictions will alert the scientists to red flag compounds. It is hoped that a guidance document for the U.S. EPA will be forthcoming to help determine the toxicity of compounds. This can be a screening tool that would rely on further testing for those compounds found by these predictions to be a phototoxic danger to health and the environment. (C) 2017 Published by Elsevier Inc. |
英文关键词 | Phototoxicity;Fullerenols;Single-walled carbon nanotubes;Ab initio calculations |
语种 | 英语 |
WOS记录号 | WOS:000406984100013 |
来源期刊 | JOURNAL OF MOLECULAR GRAPHICS & MODELLING |
来源机构 | 美国环保署 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/56732 |
作者单位 | US EPA, Natl Exposure Res Lab, Exposure Methods & Measurement Div, 944 E Harmon Ave,POB 93478, Las Vegas, NV 89193 USA |
推荐引用方式 GB/T 7714 | Betowski, Don. Predicted phototoxicities of carbon nano-material by quantum mechanical calculations[J]. 美国环保署,2017,75:102-105. |
APA | Betowski, Don.(2017).Predicted phototoxicities of carbon nano-material by quantum mechanical calculations.JOURNAL OF MOLECULAR GRAPHICS & MODELLING,75,102-105. |
MLA | Betowski, Don."Predicted phototoxicities of carbon nano-material by quantum mechanical calculations".JOURNAL OF MOLECULAR GRAPHICS & MODELLING 75(2017):102-105. |
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