气候变化领域集成服务门户

The prevalence of a sedentary (SED) life style combined with calorically rich diets has spurred the rise in childhood obesity, which, in turn, translates to adverse health effects in adulthood. Obesity and lack of active (ACT) lifestyle may increase susceptibility to air pollutants. We housed 22-day-old female Long-Evans rats in a cage without (SED) or with a running wheel (ACT). After 10 wk the rats ran 310 +/- 16.3 km. Responses of SED and ACT rats to whole-body O-3 (0, 0.25, 0.5, or 1.0 ppm; 5 h/day for 2 days) was assessed. Glucose tolerance testing (GTT) was performed following the first day of O-3. ACT rats had less body fat and an improved glucose GTT. Ventilatory function (plethysmography) of SED and ACT groups was similarly impaired by O-3. Bronchoalveolar lavage fluid (BALF) was collected after the second O-3 exposure. SED and ACT rats were hyperglycemic following 1.0 ppm O-3. GTT was impaired by O-3 in both groups; however, ACT rats exhibited improved recovery to 0.25 and 1.0 ppm O-3. BALF cell neutrophils and total cells were similarly increased in ACT and SED groups exposed to 1.0 ppm O-3. O-3-induced increase in eosinophils was exacerbated in SED rats. Chronic exercise from postweaning to adulthood improved some of the metabolic and pulmonary responses to O-3 (GTT and eosinophils) but several other parameters were unaffected. The reduction in O-3-induced rise in BALF eosinophils in ACT rats suggests a possible link between a SED lifestyle and incidence of asthma-related symptoms from O-3.