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Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines | |
Bradlow, HL; Davis, D; Sepkovic, DW; Tiwari, R; Osborne, MP | |
发表日期 | 1997 |
ISSN | 0305-750X |
卷号 | 208期号:1-2页码:9-14 |
英文摘要 | As interest in the properties of xenoestrogenic compounds has grown, different in vitro cell culture systems have been proposed as models, against which to gauge relative estrogenic impact. Previous research indicated that some organochlorine-based pesticides elevated the production of 16 alpha-hydroxyestrone relative to 2-hydroxyestrone in ER+ MCF-7 breast cancer cells while phytochemicals like indole-3-carbinol reduced this ratio. That this ratio may be a biological marker of the risk of breast cancer has recently been demonstrated. In this study we have carried out the same paradigm in two ER- cell lines to examine the effect of receptor status. To determine whether the impact of chlorinated pesticides can be modulated by phytochemical, the ability of indole-3-carbinol or brassinin to reverse the changes in metabolism was examined. Non-persisting phosphorus-based pesticides were also studied and shown not to have an effect on estrogen metabolism. The implications of these findings are examined. (C) 1997 Elsevier Science B.V. |
英文关键词 | pesticides;estrogen metabolism;cell culture;hydroxylation |
语种 | 英语 |
WOS记录号 | WOS:000072230000002 |
来源期刊 | SCIENCE OF THE TOTAL ENVIRONMENT
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来源机构 | 世界资源研究所 |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/56037 |
作者单位 | (1)Strang Canc Res Lab, New York, NY USA;(2)World Resources Inst, Washington, DC 20006 USA |
推荐引用方式 GB/T 7714 | Bradlow, HL,Davis, D,Sepkovic, DW,et al. Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines[J]. 世界资源研究所,1997,208(1-2):9-14. |
APA | Bradlow, HL,Davis, D,Sepkovic, DW,Tiwari, R,&Osborne, MP.(1997).Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines.SCIENCE OF THE TOTAL ENVIRONMENT,208(1-2),9-14. |
MLA | Bradlow, HL,et al."Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines".SCIENCE OF THE TOTAL ENVIRONMENT 208.1-2(1997):9-14. |
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