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DOI | 10.1186/s12864-024-10171-y |
High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China | |
Ma, Ying; Liu, Pengbo; Li, Ziyan; Yue, Yujuan; Zhao, Yanmei; He, Jian; Zhao, Jiaxin; Song, Xiuping; Wang, Jun; Liu, Qiyong; Lu, Liang | |
发表日期 | 2024 |
ISSN | 1471-2164 |
起始页码 | 25 |
结束页码 | 1 |
卷号 | 25期号:1 |
英文摘要 | Plague, as an ancient zoonotic disease caused by Yersinia pestis, has brought great disasters. The natural plague focus of Marmota himalayana in the Qinghai-Tibet Plateau is the largest, which has been constantly active and the leading source of human plague in China for decades. Understanding the population genetics of M. himalayana and relating that information to the biogeographic distribution of Yersinia pestis and plague outbreaks are greatly beneficial for the knowledge of plague spillover and arecrucial for pandemic prevention. In the present research, we assessed the population genetics of M. himalayana. We carried out a comparative study of plague outbreaks and the population genetics of M. himalayana on the Qinghai-Tibet Plateau. We found that M. himalayana populations are divided into two main clusters located in the south and north of the Qinghai-Tibet Plateau. Fourteen DFR genomovars of Y. pestis were found and exhibited a significant region-specific distribution. Additionally, the increased genetic diversity of plague hosts is positively associated with human plague outbreaks. This insight gained can improve our understanding of biodiversity for pathogen spillover and provide municipally directed targets for One Health surveillance development, which will be an informative next step toward increased monitoring of M. himalayana dynamics. |
英文关键词 | Zoonotic spillover; Marmota himalayana; Population genetics; Yersinia pestis; Plague |
语种 | 英语 |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS记录号 | WOS:001181358600002 |
来源期刊 | BMC GENOMICS
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/307671 |
作者单位 | Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Wuhan University |
推荐引用方式 GB/T 7714 | Ma, Ying,Liu, Pengbo,Li, Ziyan,et al. High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China[J],2024,25(1). |
APA | Ma, Ying.,Liu, Pengbo.,Li, Ziyan.,Yue, Yujuan.,Zhao, Yanmei.,...&Lu, Liang.(2024).High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China.BMC GENOMICS,25(1). |
MLA | Ma, Ying,et al."High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China".BMC GENOMICS 25.1(2024). |
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