气候变化领域集成服务门户(CCPortal): High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China

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DOI	10.1186/s12864-024-10171-y
	High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China
	Ma, Ying; Liu, Pengbo; Li, Ziyan; Yue, Yujuan; Zhao, Yanmei; He, Jian; Zhao, Jiaxin; Song, Xiuping; Wang, Jun; Liu, Qiyong; Lu, Liang
发表日期	2024
ISSN	1471-2164
起始页码	25
结束页码	1
卷号	25 期号:1
英文摘要	Plague, as an ancient zoonotic disease caused by Yersinia pestis, has brought great disasters. The natural plague focus of Marmota himalayana in the Qinghai-Tibet Plateau is the largest, which has been constantly active and the leading source of human plague in China for decades. Understanding the population genetics of M. himalayana and relating that information to the biogeographic distribution of Yersinia pestis and plague outbreaks are greatly beneficial for the knowledge of plague spillover and arecrucial for pandemic prevention. In the present research, we assessed the population genetics of M. himalayana. We carried out a comparative study of plague outbreaks and the population genetics of M. himalayana on the Qinghai-Tibet Plateau. We found that M. himalayana populations are divided into two main clusters located in the south and north of the Qinghai-Tibet Plateau. Fourteen DFR genomovars of Y. pestis were found and exhibited a significant region-specific distribution. Additionally, the increased genetic diversity of plague hosts is positively associated with human plague outbreaks. This insight gained can improve our understanding of biodiversity for pathogen spillover and provide municipally directed targets for One Health surveillance development, which will be an informative next step toward increased monitoring of M. himalayana dynamics.
英文关键词	Zoonotic spillover; Marmota himalayana; Population genetics; Yersinia pestis; Plague
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:001181358600002
来源期刊	BMC GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/307671
作者单位	Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Wuhan University
推荐引用方式 GB/T 7714	Ma, Ying,Liu, Pengbo,Li, Ziyan,et al. High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China[J],2024,25(1).
APA	Ma, Ying.,Liu, Pengbo.,Li, Ziyan.,Yue, Yujuan.,Zhao, Yanmei.,...&Lu, Liang.(2024).High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China.BMC GENOMICS,25(1).
MLA	Ma, Ying,et al."High genetic diversity of the himalayan marmot relative to plague outbreaks in the Qinghai-Tibet Plateau, China".BMC GENOMICS 25.1(2024).