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DOI	10.1016/j.ijmm.2024.151597
	Pasteurella multocida strains of a novel capsular serotype and lethal to Marmota himalayana on Qinghai-Tibet plateau in China
	Duan, Ran; Lyu, Dongyue; Qin, Shuai; Liang, Junrong; Gu, Wenpeng; Duan, Qun; Wu, Weiwei; Tang, Deming; Han, Haonan; Zheng, Xiaojin; Xi, Jinxiao; Bukai, Asaiti; Lu, Xinmin; Zhang, Peng; Zhang, Dan; Xiao, Meng; Jing, Huaiqi; Wang, Xin
发表日期	2024
ISSN	1438-4221
EISSN	1618-0607
起始页码	314
卷号	314
英文摘要	Pasteurella multocida is a zoonotic pathogen causing serious diseases in humans and animals. Here, we report P. multocida from wildlife on China's Qinghai-Tibet plateau with a novel capsular serotype, forming a single branch on the core-genome phylogenetic tree: four strains isolated from dead Himalayan marmot (Marmota himalayana) and one genome assembled from metagenomic sequencing of a dead Woolly hare (Lepus oiostolus). Four of the strains were identified as subspecies multocida and one was septica. The mouse model showed that the challenge strain killed mice within 24 h at an infectious dose of less than 300 bacteria. The short disease course is comparable to septicemic plague: the host has died before more severe pathological changes could take place. Though pathological changes were relatively mild, cytokine storm was obvious with a significant rise of IL-12p70, IL-6, TNF-alpha and IL-10 (P < 0.05). Our findings suggested P. multocida is a lethal pathogen for wildlife on Qinghai-Tibet plateau, in addition to Yersinia pestis. Individuals residing within the M. himalayana plague focus are at risk for P. multocida infection, and public health warnings are necessitated.
英文关键词	Pasteurella multocida; Qinghai-Tibet plateau; Comparative genomic analysis; Histopathology; Cytokine storm
语种	英语
WOS研究方向	Microbiology ; Virology
WOS类目	Microbiology ; Virology
WOS记录号	WOS:001164980500001
来源期刊	INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/307566
作者单位	Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention
推荐引用方式 GB/T 7714	Duan, Ran,Lyu, Dongyue,Qin, Shuai,et al. Pasteurella multocida strains of a novel capsular serotype and lethal to Marmota himalayana on Qinghai-Tibet plateau in China[J],2024,314.
APA	Duan, Ran.,Lyu, Dongyue.,Qin, Shuai.,Liang, Junrong.,Gu, Wenpeng.,...&Wang, Xin.(2024).Pasteurella multocida strains of a novel capsular serotype and lethal to Marmota himalayana on Qinghai-Tibet plateau in China.INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY,314.
MLA	Duan, Ran,et al."Pasteurella multocida strains of a novel capsular serotype and lethal to Marmota himalayana on Qinghai-Tibet plateau in China".INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 314(2024).