气候变化领域集成服务门户(CCPortal): The current status of neglected tropical diseases in Japan: A scoping review

CCPortal

DOI	10.1371/journal.pntd.0011854
	The current status of neglected tropical diseases in Japan: A scoping review
	Harada, Yuriko; Iwashita, Hanako; Moriyasu, Taeko; Nagi, Sachiyo; Saito, Nobuo; Sugawara-Mikami, Mariko; Yoshioka, Kota; Yotsu, Rie
发表日期	2024
ISSN	1935-2735
起始页码	18
结束页码	1
卷号	18 期号:1
英文摘要	Little attention has been paid to neglected tropical diseases (NTDs) in high-income countries and no literature provides an overview of NTDs in Japan. This scoping review aims to synthesize the latest evidence and information to understand epidemiology of and public health response to NTDs in Japan. Using three academic databases, we retrieved articles that mentioned NTDs in Japan, written in English or Japanese, and published between 2010 and 2020. Websites of key public health institutions and medical societies were also explored. From these sources of information, we extracted data that were relevant to answering our research questions. Our findings revealed the transmission of alveolar echinococcosis, Buruli ulcer, Chagas disease, dengue, foodborne trematodiases, mycetoma, scabies, and soil-transmitted helminthiasis as well as occurrence of snakebites within Japan. Other NTDs, such as chikungunya, cystic echinococcosis, cysticercosis, leishmaniasis, leprosy, lymphatic filariasis, rabies, and schistosomiasis, have been imported into the country. Government agencies tend to organize surveillance and control programs only for the NTDs targeted by the Infectious Disease Control Law, namely, echinococcosis, rabies, dengue, and chikungunya. At least one laboratory offers diagnostic testing for each NTD except for dracunculiasis, human African trypanosomiasis, onchocerciasis, and yaws. No medicine is approved for treatment of Chagas disease and fascioliasis and only off-label use drugs are available for cysticercosis, opisthorchiasis, human African trypanosomiasis, onchocerciasis, schistosomiasis, and yaws. Based on these findings, we developed disease-specific recommendations. In addition, three policy issues are discussed, such as lack of legal frameworks to organize responses to some NTDs, overreliance on researchers to procure some NTD products, and unaffordability of unapproved NTD medicines. Japan should recognize the presence of NTDs within the country and need to address them as a national effort. The implications of our findings extend beyond Japan, emphasizing the need to study, recognize, and address NTDs even in high-income countries. Neglected tropical diseases (NTDs) are an umbrella term for 20 diseases and disease groups recognized by the World Health Organization. Although NTDs are usually considered to be a public health problem in low- and middle-income countries, people living in high-income countries could also be affected. In this scoping review, we aimed to summarize the latest evidence and information to understand the epidemiology of and public health response to NTDs in Japan. Japan officially reported a yearly average of 340 NTD cases between 2014 and 2017; however, we found that it does not accurately reflect the current status of NTDs in the country. Our review suggests that 15 of 20 NTDs can be considered to be important public health concerns. While echinococcosis, chikungunya, dengue, and rabies are under control by law, many other NTDs are largely neglected by Japan's health systems and solely addressed by a limited number of physicians and researchers. We recommend that the Government of Japan should assume responsibility for enhancing surveillance, expanding access to diagnostics and medicines, and ensuring affordability of unapproved NTD drugs.
语种	英语
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS类目	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS记录号	WOS:001135946700008
来源期刊	PLOS NEGLECTED TROPICAL DISEASES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/306655
作者单位	Tokyo Women's Medical University; Nagasaki University; Nagasaki University; Oita University; Teikyo University; Nagasaki University; Nagasaki University; Tulane University; National Center for Global Health & Medicine - Japan
推荐引用方式 GB/T 7714	Harada, Yuriko,Iwashita, Hanako,Moriyasu, Taeko,et al. The current status of neglected tropical diseases in Japan: A scoping review[J],2024,18(1).
APA	Harada, Yuriko.,Iwashita, Hanako.,Moriyasu, Taeko.,Nagi, Sachiyo.,Saito, Nobuo.,...&Yotsu, Rie.(2024).The current status of neglected tropical diseases in Japan: A scoping review.PLOS NEGLECTED TROPICAL DISEASES,18(1).
MLA	Harada, Yuriko,et al."The current status of neglected tropical diseases in Japan: A scoping review".PLOS NEGLECTED TROPICAL DISEASES 18.1(2024).