气候变化领域集成服务门户(CCPortal): Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood

CCPortal

DOI	10.3390/ani14091365
	Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood
	Liu, Yili; Ma, Liangliang; Riqing, Daojie; Qu, Jiu; Chen, Jiyong; Zhandu, Danzeng; Li, Biao; Jiang, Mingfeng
发表日期	2024
ISSN	2076-2615
起始页码	14
结束页码	9
卷号	14 期号:9
英文摘要	Simple Summary Minerals are essential for maintaining the health and productivity of livestock. Yaks are mainly grazed rotationally in the Qinghai-Tibet Plateau, but the natural forage nutrients in the alpine meadow are seasonal and even different every month, and the nutritional requirements of yaks at different ages are different. Therefore, it is very important to understand how host genes and microorganisms in the rumen of yaks at different ages coordinate to regulate the metabolism of mineral elements and other nutrients. In this study, we performed transcriptome and metagenomic analyses of the rumen and its contents at different age stages to explore the synergistic regulation of mineral metabolism by host genes and microorganisms. In total, 13 bacteria and 22 host genes were mainly involved in the regulation of metal ion binding. The results of this study are of great significance for the improvement of supplementary feeding and growth performance of yaks at different ages.Abstract Yaks are the main pillar of plateau animal husbandry and the material basis of local herdsmen's survival. The level of mineral elements in the body is closely related to the production performance of yaks. In this study, we performed a comprehensive analysis of rumen epithelial morphology, transcriptomics and metagenomics to explore the dynamics of rumen functions, microbial colonization and functional interactions in yaks from birth to adulthood. Bacteria, eukaryotes, archaea and viruses colonized the rumen of yaks from birth to adulthood, with bacteria being the majority. Bacteroidetes and Firmicutes were the dominant phyla in five developmental stages, and the abundance of genus Lactobacillus and Fusobacterium significantly decreased with age. Glycoside hydrolase (GH) genes were the most highly represented in five different developmental stages, followed by glycosyltransferases (GTs) and carbohydrate-binding modules (CBMs), where the proportion of genes coding for CBMs increased with age. Integrating host transcriptome and microbial metagenome revealed 30 gene modules related to age, muscle layer thickness, nipple length and width of yaks. Among these, the MEmagenta and MEturquoise were positively correlated with these phenotypic traits. Twenty-two host genes involved in transcriptional regulation related to metal ion binding (including potassium, sodium, calcium, zinc, iron) were positively correlated with a rumen bacterial cluster 1 composed of Alloprevotella, Paludibacter, Arcobacter, Lactobacillus, Bilophila, etc. Therefore, these studies help us to understand the interaction between rumen host and microorganisms in yaks at different ages, and further provide a reliable theoretical basis for the development of feed and mineral element supplementation for yaks at different ages.
英文关键词	yaks; rumen; age; transcriptome; metagenomic; ion binding
语种	英语
WOS研究方向	Agriculture ; Veterinary Sciences ; Zoology
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences ; Zoology
WOS记录号	WOS:001219789000001
来源期刊	ANIMALS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/306453
作者单位	Southwest Minzu University; Southwest Minzu University
推荐引用方式 GB/T 7714	Liu, Yili,Ma, Liangliang,Riqing, Daojie,et al. Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood[J],2024,14(9).
APA	Liu, Yili.,Ma, Liangliang.,Riqing, Daojie.,Qu, Jiu.,Chen, Jiyong.,...&Jiang, Mingfeng.(2024).Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood.ANIMALS,14(9).
MLA	Liu, Yili,et al."Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood".ANIMALS 14.9(2024).