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| DOI | 10.1038/s41598-024-58028-4 |
| Significance of dietary quinoa husk (Chenopodium quinoa) in gene regulation for stress mitigation in fish | |
| 发表日期 | 2024 |
| ISSN | 2045-2322 |
| 起始页码 | 14 |
| 结束页码 | 1 |
| 卷号 | 14期号:1 |
| 英文摘要 | The persistent challenges posed by pollution and climate change are significant factors disrupting ecosystems, particularly aquatic environments. Numerous contaminants found in aquatic systems, such as ammonia and metal toxicity, play a crucial role in adversely affecting aquaculture production. Against this backdrop, fish feed was developed using quinoa husk (the byproduct of quinoa) as a substitute for fish meal. Six isonitrogenous diets (30%) and isocaloric diets were formulated by replacing fish meal with quinoa husk at varying percentages: 0% quinoa (control), 15, 20, 25, 30 and 35%. An experiment was conducted to explore the potential of quinoa husk in replacing fish meal and assess its ability to mitigate ammonia and arsenic toxicity as well as high-temperature stress in Pangasianodon hypophthalmus. The formulated feed was also examined for gene regulation related to antioxidative status, immunity, stress proteins, growth regulation, and stress markers. The gene regulation of sod, cat, and gpx in the liver was notably upregulated under concurrent exposure to ammonia, arsenic, and high-temperature (NH3 + As + T) stress. However, quinoa husk at 25% downregulated sod, cat, and gpx expression compared to the control group. Furthermore, genes associated with stress proteins HSP70 and DNA damage-inducible protein (DDIP) were significantly upregulated in response to stressors (NH3 + As + T), but quinoa husk at 25% considerably downregulated HSP70 and DDIP to mitigate the impact of stressors. Growth-responsive genes such as myostatin (MYST) and somatostatin (SMT) were remarkably downregulated, whereas growth hormone receptor (GHR1 and GHR beta), insulin-like growth factors (IGF1X, IGF2X), and growth hormone gene were significantly upregulated with quinoa husk at 25%. The gene expression of apoptosis (Caspase 3a and Caspase 3b) and nitric oxide synthase (iNOS) were also noticeably downregulated with quinoa husk (25%) reared under stressful conditions. Immune-related gene expression, including immunoglobulin (Ig), toll-like receptor (TLR), tumor necrosis factor (TNF alpha), and interleukin (IL), strengthened fish immunity with quinoa husk feed. The results revealed that replacing 25% of fish meal with quinoa husk could improve the gene regulation of P. hypophthalmus involved in mitigating ammonia, arsenic, and high-temperature stress in fish. |
| 英文关键词 | Quinoa; Abiotic stress; Caspase; CYP450; iNOS; Fish |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001195796200049 |
| 来源期刊 | SCIENTIFIC REPORTS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/305176 |
| 作者单位 | Indian Council of Agricultural Research (ICAR); ICAR - National Institute of Abiotic Stress Management |
| 推荐引用方式 GB/T 7714 | . Significance of dietary quinoa husk (Chenopodium quinoa) in gene regulation for stress mitigation in fish[J],2024,14(1). |
| APA | (2024).Significance of dietary quinoa husk (Chenopodium quinoa) in gene regulation for stress mitigation in fish.SCIENTIFIC REPORTS,14(1). |
| MLA | "Significance of dietary quinoa husk (Chenopodium quinoa) in gene regulation for stress mitigation in fish".SCIENTIFIC REPORTS 14.1(2024). |
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