气候变化领域集成服务门户(CCPortal): Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance

CCPortal

DOI	10.1186/s40104-024-01025-4
	Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance
	Hernandez, Aakilah S.; Zayas, Gabriel A.; Rodriguez, Eduardo E.; Davila, Kaitlyn M. Sarlo; Rafiq, Fahad; Nunez, Andrea N.; Titto, Cristiane Goncalves; Mateescu, Raluca G.
发表日期	2024
ISSN	1674-9782
EISSN	2049-1891
起始页码	15
结束页码	1
卷号	15 期号:1
英文摘要	Background Thermal stress in subtropical regions is a major limiting factor in beef cattle production systems with around $369 million being lost annually due to reduced performance. Heat stress causes numerous physiological and behavioral disturbances including reduced feed intake and decreased production levels. Cattle utilize various physiological mechanisms such as sweating to regulate internal heat. Variation in these traits can help identify genetic variants that control sweat gland properties and subsequently allow for genetic selection of cattle with greater thermotolerance.Methods This study used 2,401 Brangus cattle from two commercial ranches in Florida. Precise phenotypes that contribute to an animal's ability to manage heat stress were calculated from skin biopsies and included sweat gland area, sweat gland depth, and sweat gland length. All animals were genotyped with the Bovine GGP F250K, and BLUPF90 software was used to estimate genetic parameters and for Genome Wide Association Study.Results Sweat gland phenotypes heritability ranged from 0.17 to 0.42 indicating a moderate amount of the phenotypic variation is due to genetics, allowing producers the ability to select for favorable sweat gland properties. A weighted single-step GWAS using sliding 10 kb windows identified multiple quantitative trait loci (QTLs) explaining a significant amount of genetic variation. QTLs located on BTA7 and BTA12 explained over 1.0% of genetic variance and overlap the ADGRV1 and CCDC168 genes, respectively. The variants identified in this study are implicated in processes related to immune function and cellular proliferation which could be relevant to heat management. Breed of Origin Alleles (BOA) were predicted using local ancestry in admixed populations (LAMP-LD), allowing for identification of markers' origin from either Brahman or Angus ancestry. A BOA GWAS was performed to identify regions inherited from particular ancestral breeds that might have a significant impact on sweat gland phenotypes.Conclusions The results of the BOA GWAS indicate that both Brahman and Angus alleles contribute positively to sweat gland traits, as evidenced by favorable marker effects observed from both genetic backgrounds. Understanding and utilizing genetic traits that confer better heat tolerance is a proactive approach to managing the impacts of climate change on livestock farming.
英文关键词	GWAS; Heritability; Skin; Thermotolerance
语种	英语
WOS研究方向	Agriculture
WOS类目	Agriculture, Dairy & Animal Science
WOS记录号	WOS:001215449100001
来源期刊	JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/305102
作者单位	North Carolina State University; State University System of Florida; University of Florida; United States Department of Agriculture (USDA); Universidade de Sao Paulo
推荐引用方式 GB/T 7714	Hernandez, Aakilah S.,Zayas, Gabriel A.,Rodriguez, Eduardo E.,et al. Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance[J],2024,15(1).
APA	Hernandez, Aakilah S..,Zayas, Gabriel A..,Rodriguez, Eduardo E..,Davila, Kaitlyn M. Sarlo.,Rafiq, Fahad.,...&Mateescu, Raluca G..(2024).Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance.JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY,15(1).
MLA	Hernandez, Aakilah S.,et al."Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance".JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY 15.1(2024).