气候变化领域集成服务门户(CCPortal): Identification and postnatal developmental characteristics of brown adipose tissue in yak calves

CCPortal

DOI	10.1002/vms3.1356
	Identification and postnatal developmental characteristics of brown adipose tissue in yak calves
	Chen, Fuju; Zhao, Yutian; Ling, Xiaodong
发表日期	2024
EISSN	2053-1095
起始页码	10
结束页码	2
卷号	10 期号:2
英文摘要	BackgroundBrown adipose tissue (BAT) provides newborn mammals with a critical capacity for non-shivering thermogenesis and enables their adaptation to the cold of the extrauterine environment. The domestic yak (Bos grunniens) has evolved on the Qinghai-Tibet Plateau and has adapted well to extremely cold and hypoxic environments. However, the location, characterization and postnatal development of BAT in yak calves remain largely unknown.MethodsWe identified different types of adipocytes and explored the postnatal development of interscapular and subcutaneous adipose tissue in yak calves at 1, 7 and 30 days old using morphological and molecular biology methods.ResultsThe results show that multilocular and unilocular adipocytes were found in two depots. Multilocular adipocytes contained small lipid droplets packed with numerous mitochondria. However, unilocular adipocytes contained a single unilocular lipid droplet and few mitochondria. The number of multilocular adipocytes significantly decreased, whereas the number of unilocular adipocytes significantly increased from day 1 to 30. Furthermore, uncoupling protein 1 (UCP1) expressions in both multilocular and unilocular adipocytes, as well as UCP1 mRNA and protein expression, were significantly decreased from day 1 to 30. In addition, peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and peroxisome proliferator-activated receptor alpha mRNA expression were significantly decreased.ConclusionsThe results of the research indicate that adipocytes in both newborn yak calf interscapular and subcutaneous adipose tissue are multilocular adipocytes. Many multilocular adipocytes were transformed into unilocular adipocytes after birth, but some multilocular adipocytes remained at day 30; this transition occurred at different rates in different depots. These results provide a basis for further study of BAT in yak calves. Brown adipose tissue (BAT) provides newborn mammals with a critical capacity for non-shivering thermogenesis and enables their adaptation to the cold of the extrauterine environment. In this study, we identification the BAT and study the postnatal developmental characteristics of interscapular and subcutaneous BAT in yak calves at 1, 7 and 30 days old using morphological and molecular biology methods. The results provide a basis for further study of BAT in yak calves. image
英文关键词	yak calf; brown adipocyte; white adipocyte; uncoupling protein 1
语种	英语
WOS研究方向	Veterinary Sciences
WOS类目	Veterinary Sciences
WOS记录号	WOS:001153217600001
来源期刊	VETERINARY MEDICINE AND SCIENCE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/304989
作者单位	Qinghai University; Qinghai University
推荐引用方式 GB/T 7714	Chen, Fuju,Zhao, Yutian,Ling, Xiaodong. Identification and postnatal developmental characteristics of brown adipose tissue in yak calves[J],2024,10(2).
APA	Chen, Fuju,Zhao, Yutian,&Ling, Xiaodong.(2024).Identification and postnatal developmental characteristics of brown adipose tissue in yak calves.VETERINARY MEDICINE AND SCIENCE,10(2).
MLA	Chen, Fuju,et al."Identification and postnatal developmental characteristics of brown adipose tissue in yak calves".VETERINARY MEDICINE AND SCIENCE 10.2(2024).