气候变化领域集成服务门户(CCPortal): A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease

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DOI	10.3390/v16030341
	A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease
	Pelz, Johann Otto; Muehlberg, Christoph; Friedrich, Isabel; Weidhase, Lorenz; Zimmermann, Silke; Maier, Melanie; Pietsch, Corinna
发表日期	2024
EISSN	1999-4915
起始页码	16
结束页码	3
卷号	16 期号:3
英文摘要	Background: Viral meningitis/encephalitis (ME) is a rare but potentially harmful disease. The prompt identification of the respective virus is important to guide not only treatment but also potential public health countermeasures. However, in about 40% of cases, no virus is identified despite an extensive diagnostic workup. The aim of the present study was to analyze demographic, seasonal, and routine cerebrospinal fluid (CSF) parameters in cases of viral ME and assess their utility for the prediction of the causative virus. Methods: Demographic data, season, and routine CSF parameters (total leucocytes, CSF cell differentiation, age-adjusted CSF/serum albumin ratio, and total immunoglobulin ratios) were retrospectively assessed in cases of viral ME. Results: In total, 156 cases of acute viral ME (74 female, median age 40.0 years) were treated at a tertiary-care hospital in Germany. Specific viral infections were detected in 93 (59.6%) cases. Of these, 14 (9.0%) cases were caused by herpes simplex virus (HSV), 36 (23.1%) by varicella-zoster virus (VZV), 27 (17.3%) by enteroviruses, 9 (5.8%) by West Nile virus (WNV), and 7 (4.5%) by other specific viruses. Additionally, 64 (41.0%) cases of ME of unknown viral etiology were diagnosed. Cases of WNV ME were older, predominantly male, showed a severe disruption of the blood-CSF-barrier, a high proportion of neutrophils in CSF, and an intrathecal total immunoglobulin M synthesis in the first CSF sample. In a multinominal logistic regression analysis, the accuracy of these CSF parameters together with age and seasonality was best for the prediction of WNV (87.5%), followed by unknown viral etiology (66.7%), VZV (61.8%), and enteroviruses (51.9%). Conclusions: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV.
英文关键词	West Nile virus; meningitis; encephalitis; cerebrospinal fluid; climate change; immunoglobulin M
语种	英语
WOS研究方向	Virology
WOS类目	Virology
WOS记录号	WOS:001193000600001
来源期刊	VIRUSES-BASEL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/304585
作者单位	Leipzig University; Leipzig University; Leipzig University; Leipzig University
推荐引用方式 GB/T 7714	Pelz, Johann Otto,Muehlberg, Christoph,Friedrich, Isabel,et al. A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease[J],2024,16(3).
APA	Pelz, Johann Otto.,Muehlberg, Christoph.,Friedrich, Isabel.,Weidhase, Lorenz.,Zimmermann, Silke.,...&Pietsch, Corinna.(2024).A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease.VIRUSES-BASEL,16(3).
MLA	Pelz, Johann Otto,et al."A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease".VIRUSES-BASEL 16.3(2024).