气候变化领域集成服务门户(CCPortal): The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections

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DOI	10.3389/fcimb.2024.1369615
	The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections
	Saleh, Mona; Hummel, Karin; Schlosser, Sarah; Razzazi-Fazeli, Ebrahim; Bartholomew, Jerri L.; Holzer, Astrid; Secombes, Christopher J.; El-Matbouli, Mansour
发表日期	2024
ISSN	2235-2988
起始页码	14
卷号	14
英文摘要	Introduction: Little is known about the proteomic changes at the portals of entry in rainbow trout after infection with the myxozoan parasites, Myxobolus cerebralis, and Tetracapsuloides bryosalmonae. Whirling disease (WD) is a severe disease of salmonids, caused by the myxosporean M. cerebralis, while, proliferative kidney disease (PKD) is caused by T. bryosalmonae, which instead belongs to the class Malacosporea. Climate change is providing more suitable conditions for myxozoan parasites lifecycle, posing a high risk to salmonid aquaculture and contributing to the decline of wild trout populations in North America and Europe. Therefore, the aim of this study was to provide the first proteomic profiles of the host in the search for evasion strategies during single and coinfection with M. cerebralis and T. bryosalmonae. Methods: One group of fish was initially infected with M. cerebralis and another group with T. bryosalmonae. After 30 days, half of the fish in each group were co-infected with the other parasite. Using a quantitative proteomic approach, we investigated proteomic changes in the caudal fins and gills of rainbow trout before and after co-infection. Results: In the caudal fins, 16 proteins were differentially regulated post exposure to M. cerebralis, whereas 27 proteins were differentially modulated in the gills of the infected rainbow trout post exposure to T. bryosalmonae. After co-infection, 4 proteins involved in parasite recognition and the regulation of host immune responses were differentially modulated between the groups in the caudal fin. In the gills, 11 proteins involved in parasite recognition and host immunity, including 4 myxozoan proteins predicted to be virulence factors, were differentially modulated. Discussion: The results of this study increase our knowledge on rainbow trout co-infections by myxozoan parasites and rainbow trout immune responses against myxozoans at the portals of entry, supporting a better understanding of these host-parasite interactions.
英文关键词	salmonids; proteome; immunomodulation; proliferative kidney disease; whirling disease
语种	英语
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
WOS记录号	WOS:001231865200001
来源期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/304006
作者单位	University of Veterinary Medicine Vienna; University of Veterinary Medicine Vienna; Oregon State University; University of Aberdeen
推荐引用方式 GB/T 7714	Saleh, Mona,Hummel, Karin,Schlosser, Sarah,et al. The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections[J],2024,14.
APA	Saleh, Mona.,Hummel, Karin.,Schlosser, Sarah.,Razzazi-Fazeli, Ebrahim.,Bartholomew, Jerri L..,...&El-Matbouli, Mansour.(2024).The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,14.
MLA	Saleh, Mona,et al."The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 14(2024).