气候变化领域集成服务门户(CCPortal): Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study

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DOI	10.1186/s12872-024-03886-z
	Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study
	Sun, Yanqiu; Zhang, Chenhong; He, Bo; Wang, Lei; Tian, Dengfeng; Kang, Zhiqiang; Chen, Lixin; Li, Ruiwen; Ren, Jialiang; Guo, Yong; Zhang, Yonghai; Duojie, Dingda; Zhang, Qiang; Gao, Fabao
发表日期	2024
ISSN	1471-2261
起始页码	24
结束页码	1
卷号	24 期号:1
英文摘要	Background Long-term exposure to a high altitude environment with low pressure and low oxygen could cause abnormalities in the structure and function of the heart. Myocardial strain is a sensitive indicator for assessing myocardial dysfunction, monitoring myocardial strain is of great significance for the early diagnosis and treatment of high altitude heart-related diseases. This study applies cardiac magnetic resonance tissue tracking technology (CMR-TT) to evaluate the changes in left ventricular myocardial function and structure in rats in high altitude environment. Methods 6-week-old male rats were randomized into plateau hypoxia rats (plateau group, n = 21) as the experimental group and plain rats (plain group, n = 10) as the control group. plateau group rats were transported from Chengdu (altitude: 360 m), a city in a plateau located in southwestern China, to the Qinghai-Tibet Plateau (altitude: 3850 m), Yushu, China, and then fed for 12 weeks there, while plain group rats were fed in Chengdu(altitude: 360 m), China. Using 7.0 T cardiac magnetic resonance (CMR) to evaluate the left ventricular ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV) and stroke volume (SV), as well as myocardial strain parameters including the peak global longitudinal (GLS), radial (GRS), and circumferential strain (GCS). The rats were euthanized and a myocardial biopsy was obtained after the magnetic resonance imaging scan. Results The plateau rats showed more lower left ventricular GLS and GRS (P < 0.05) than the plain rats. However, there was no statistically significant difference in left ventricular EDV, ESV, SV, EF and GCS compared to the plain rats (P > 0.05). Conclusions After 12 weeks of exposure to high altitude low-pressure hypoxia environment, the left ventricular global strain was partially decreased and myocardium is damaged, while the whole heart ejection fraction was still preserved, the myocardial strain was more sensitive than the ejection fraction in monitoring cardiac function.
英文关键词	Plateau; Cardiac magnetic resonance; Tissue tracking; Ventricular function; Myocardial strain
语种	英语
WOS研究方向	Cardiovascular System & Cardiology
WOS类目	Cardiac & Cardiovascular Systems
WOS记录号	WOS:001207754200001
来源期刊	BMC CARDIOVASCULAR DISORDERS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/303641
作者单位	Sichuan University; General Electric
推荐引用方式 GB/T 7714	Sun, Yanqiu,Zhang, Chenhong,He, Bo,et al. Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study[J],2024,24(1).
APA	Sun, Yanqiu.,Zhang, Chenhong.,He, Bo.,Wang, Lei.,Tian, Dengfeng.,...&Gao, Fabao.(2024).Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study.BMC CARDIOVASCULAR DISORDERS,24(1).
MLA	Sun, Yanqiu,et al."Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study".BMC CARDIOVASCULAR DISORDERS 24.1(2024).