气候变化领域集成服务门户(CCPortal): Investigation of molecular changes in the brain tissue of Transylvanian naked neck chicken caused by heat conditioning

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DOI	10.56385/magyallory.2024.02.67-75
	Investigation of molecular changes in the brain tissue of Transylvanian naked neck chicken caused by heat conditioning
	Nikolett, Tokodyne Szabadi; Roland, Toth; Bence, Lazar; Andras, Ecker; Martin, Urban; Eszter, Varkonyi; Krisztina, Liptoi; Elen, Gocza
发表日期	2024
ISSN	0025-004X
起始页码	146
结束页码	2
卷号	146 期号:2
英文摘要	Background: Climate change due to global warming has an increasing impact on the poultry sector. The decrease in the number of eggs, the deterioration of the meat quality of farm animals and the increase in mortality cause serious losses in farms. Many experiments have been aimed at improving heat tolerance in poultry. Literature data prove the effectiveness of heat treatment, but the molecular pathways underlying the mechanism are not fully understood yet. Objectives: The aim of our research is to investigate the defence mechanisms activated by heat treatment in brain tissue samples of chickens by comparing the expression patterns of heat shock proteins and factors, as well as miRNAs. We believe these are biomarkers of heat stress, and their investigation can help to reveal the molecular processes behind heat tolerance in animals. Materials and Methods: Fertilized eggs of Transylvanian Naked Neck Chicken were incubated at 37.5 degrees C at 60% humidity (at NBGC IFC in Hungary). After hatching, the animals of the control (C) group were kept under normal conditions. The heat treatment group (HT) was heat-conditioned (38.5 degrees C) for 12 hours at the age of 2 days, and sampling took place after treatment (chicks) and at 23-week-old. The expression of heat stress-induced genes in the brain tissues of the heat-treated and control animals were examined. Results and Discussion: Our results indicate that the expression of HSP70 in the brain tissue of 2-day-old chickens was higher in the heat-treated group than in the control group. Lower miR-138 expression was observed in heat-treated adult male chickens compared to controls. We found that miR-138 is a suitable biomarker for signalling path kays involved in heat stress, such as HSP70. As a next step, there are plans to conduct microarray analysis of microRNAs to search for heat-related miRNAs in the upcoming generation.
语种	英语
WOS研究方向	Veterinary Sciences
WOS类目	Veterinary Sciences
WOS记录号	WOS:001205403100002
来源期刊	MAGYAR ALLATORVOSOK LAPJA
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/303510
推荐引用方式 GB/T 7714	Nikolett, Tokodyne Szabadi,Roland, Toth,Bence, Lazar,et al. Investigation of molecular changes in the brain tissue of Transylvanian naked neck chicken caused by heat conditioning[J],2024,146(2).
APA	Nikolett, Tokodyne Szabadi.,Roland, Toth.,Bence, Lazar.,Andras, Ecker.,Martin, Urban.,...&Elen, Gocza.(2024).Investigation of molecular changes in the brain tissue of Transylvanian naked neck chicken caused by heat conditioning.MAGYAR ALLATORVOSOK LAPJA,146(2).
MLA	Nikolett, Tokodyne Szabadi,et al."Investigation of molecular changes in the brain tissue of Transylvanian naked neck chicken caused by heat conditioning".MAGYAR ALLATORVOSOK LAPJA 146.2(2024).