气候变化领域集成服务门户(CCPortal): Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among US Residents

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DOI	10.1016/j.envint.2024.108651
	Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among US Residents
发表日期	2024
ISSN	0160-4120
EISSN	1873-6750
起始页码	187
卷号	187
英文摘要	Background: Air pollution is a recognized risk factor for cardiovascular disease (CVD). Temperature is also linked to CVD, with a primary focus on acute effects. Despite the close relationship between air pollution and temperature, their health effects are often examined separately, potentially overlooking their synergistic effects. Moreover, fewer studies have performed mixture analysis for multiple co-exposures, essential for adjusting confounding effects among them and assessing both cumulative and individual effects. Methods: We obtained hospitalization records for residents of 14 U.S. states, spanning 2000-2016, from the Health Cost and Utilization Project State Inpatient Databases. We used a grouped weighted quantile sum regression, a novel approach for mixture analysis, to simultaneously evaluate cumulative and individual associations of annual exposures to four grouped mixtures: air pollutants (elemental carbon, ammonium, nitrate, organic carbon, sulfate, nitrogen dioxide, ozone), differences between summer and winter temperature means and their long-term averages during the entire study period (i.e., summer and winter temperature mean anomalies), differences between summer and winter temperature standard deviations (SD) and their long-term averages during the entire study period (i.e., summer and winter temperature SD anomalies), and interaction terms between air pollutants and summer and winter temperature mean anomalies. The outcomes are hospitalization rates for four prevalent CVD subtypes: ischemic heart disease, cerebrovascular disease, heart failure, and arrhythmia. Results: Chronic exposure to air pollutant mixtures was associated with increased hospitalization rates for all CVD subtypes, with heart failure being the most susceptible subtype. Sulfate, nitrate, nitrogen dioxide, and organic carbon posed the highest risks. Mixtures of the interaction terms between air pollutants and temperature mean anomalies were associated with increased hospitalization rates for all CVD subtypes. Conclusions: Our findings identified critical pollutants for targeted emission controls and suggested that abnormal temperature changes chronically affected cardiovascular health by interacting with air pollution, not directly.
英文关键词	Cardiovascular disease; Air pollution; Temperature anomalies; Mixtures; Chronic exposure; Climate change
语种	英语
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:001232241100001
来源期刊	ENVIRONMENT INTERNATIONAL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/303000
作者单位	Harvard University; Harvard T.H. Chan School of Public Health; Icahn School of Medicine at Mount Sinai; University of Michigan System; University of Michigan; University of Missouri System; University of Missouri Kansas City; University of California System; University of California Davis; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
推荐引用方式 GB/T 7714	. Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among US Residents[J],2024,187.
APA	(2024).Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among US Residents.ENVIRONMENT INTERNATIONAL,187.
MLA	"Grouped mixtures of air pollutants and seasonal temperature anomalies and cardiovascular hospitalizations among US Residents".ENVIRONMENT INTERNATIONAL 187(2024).

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