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| DOI | 10.1371/journal.pntd.0012053 |
| Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses | |
| 发表日期 | 2024 |
| ISSN | 1935-2735 |
| 起始页码 | 18 |
| 结束页码 | 4 |
| 卷号 | 18期号:4 |
| 英文摘要 | Background Mosquito-borne arboviruses are expanding their territory and elevating their infection prevalence due to the rapid climate change, urbanization, and increased international travel and global trade. Various significant arboviruses, including the dengue virus, Zika virus, Chikungunya virus, and yellow fever virus, are all reliant on the same primary vector, Aedes aegypti. Consequently, the occurrence of arbovirus coinfection in mosquitoes is anticipated. Arbovirus coinfection in mosquitoes has two patterns: simultaneous and sequential. Numerous studies have demonstrated that simultaneous coinfection of arboviruses in mosquitoes is unlikely to exert mutual developmental influence on these viruses. However, the viruses' interplay within a mosquito after the sequential coinfection seems intricated and not well understood. Methodology/principal findings We conducted experiments aimed at examining the phenomenon of arbovirus sequential coinfection in both mosquito cell line (C6/36) and A. aegypti, specifically focusing on dengue virus (DENV, serotype 2) and Zika virus (ZIKV). We firstly observed that DENV and ZIKV can sequentially infect mosquito C6/36 cell line, but the replication level of the subsequently infected ZIKV was significantly suppressed. Similarly, A. aegypti mosquitoes can be sequentially coinfected by these two arboviruses, regardless of the order of virus exposure. However, the replication, dissemination, and the transmission potential of the secondary virus were significantly inhibited. We preliminarily explored the underlying mechanisms, revealing that arbovirus-infected mosquitoes exhibited activated innate immunity, disrupted lipid metabolism, and enhanced RNAi pathway, leading to reduced susceptibility to the secondary arbovirus infections. Conclusions/significance Our findings suggest that, in contrast to simultaneous arbovirus coinfection in mosquitoes that can promote the transmission and co-circulation of these viruses, sequential coinfection appears to have limited influence on arbovirus transmission dynamics. However, it is important to note that more experimental investigations are needed to refine and expand upon this conclusion. |
| 语种 | 英语 |
| WOS研究方向 | Infectious Diseases ; Parasitology ; Tropical Medicine |
| WOS类目 | Infectious Diseases ; Parasitology ; Tropical Medicine |
| WOS记录号 | WOS:001194662500002 |
| 来源期刊 | PLOS NEGLECTED TROPICAL DISEASES
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/302485 |
| 作者单位 | Jinan University; Sun Yat Sen University |
| 推荐引用方式 GB/T 7714 | . Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses[J],2024,18(4). |
| APA | (2024).Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses.PLOS NEGLECTED TROPICAL DISEASES,18(4). |
| MLA | "Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses".PLOS NEGLECTED TROPICAL DISEASES 18.4(2024). |
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