Climate Change Data Portal
| DOI | 10.1016/j.heliyon.2024.e26564 |
| Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites | |
| 发表日期 | 2024 |
| EISSN | 2405-8440 |
| 起始页码 | 10 |
| 结束页码 | 5 |
| 卷号 | 10期号:5 |
| 英文摘要 | Diarrhea is a severe issue in calves that causes fertility problems and economic issues worldwide. Sodium acetate/sodium butyrate (SA/SB) alleviates diarrhea in mice; however, little information is available about the preventive effect of SA/SB on diarrheic yak calves living on the Tibet plateau. Yak calves (n = 19) of age >= 4 months and weight 37 +/- 2 Kg were randomly divided into control (C, n = 10) and supplement groups (S, n = 9). Yaks belonging to the supplement group were given sodium butyrate (10 g/kg) and sodium acetate (5 g/kg) for 28 days, along with normal feed, seasonal grasses, pasture, and water. The blood and fecal samples from yak calves were collected for assessment of antioxidant capacity, inflammatory cytokines, microbiome, and short-chain fatty acids (SCFAs) concentration analysis. Results of this study revealed that a lower diarrhea rate, higher weight, and net weight gain were recorded in yaks belonging to group S supplemented with SA/SB. Similarly, increased antioxidant capacity with higher levels of T-AOC, SOD, and GSH-px and decreased inflammatory reactions by decreasing both TNF-alpha and IL-1 beta concentrations were recorded in yaks of group S. The concentration of SCFAs was significantly higher (p < 0.05) in yaks from group S than group C. Microbiome analysis revealed that 8 phyla and 54 genera were significantly different (p < 0.05) in both yak groups, with increased probiotics (Akkermansia, Oscillospira), SCFAs producing genera (Oscillospira, ASF356, Anaerosporobacter and Phascolarctobacterium), and decreased inflammatory related genus (Flavonifractor, Fournierella) and harmful bacteria (Oscillibacter, Achromobacter) in group S. In conclusion, the results demonstrated that SA and SB could decrease diarrhea rates in yak calves on the plateau via increasing antioxidant ability and SCFAs, while decreasing inflammatory responses in yaks by moderating gut microbiota. The current results provide new insights for the prevention and treatment of diarrhea in yaks. |
| 英文关键词 | Diarrhea; Yak; Sodium acetate; Sodium butyrate; Microbiota; SCFAs |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001202024200001 |
| 来源期刊 | HELIYON
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/301792 |
| 作者单位 | Tibet Agriculture & Animal Husbandry University; Nanjing Agricultural University; Nanjing Agricultural University; Tibet Academy of Agriculture & Animal Husbandry Sciences; Islamia University of Bahawalpur; King Saud University |
| 推荐引用方式 GB/T 7714 | . Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites[J],2024,10(5). |
| APA | (2024).Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites.HELIYON,10(5). |
| MLA | "Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites".HELIYON 10.5(2024). |
| 条目包含的文件 | 条目无相关文件。 | |||||
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
