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DOI10.1093/molbev/msae009
Genetically Encoded Lizard Color Divergence for Camouflage and Thermoregulation
Sun, Bao-Jun; Li, Wei-Ming; Lv, Peng; Wen, Guan-Nan; Wu, Dan-Yang; Tao, Shi-Ang; Liao, Ming-Ling; Yu, Chang-Qing; Jiang, Zhong-Wen; Wang, Yang; Xie, Hong-Xin; Wang, Xi-Feng; Chen, Zhi-Qiang; Liu, Feng; Du, Wei-Guo
发表日期2024
ISSN0737-4038
EISSN1537-1719
起始页码41
结束页码2
卷号41期号:2
英文摘要Local adaptation is critical in speciation and evolution, yet comprehensive studies on proximate and ultimate causes of local adaptation are generally scarce. Here, we integrated field ecological experiments, genome sequencing, and genetic verification to demonstrate both driving forces and molecular mechanisms governing local adaptation of body coloration in a lizard from the Qinghai-Tibet Plateau. We found dark lizards from the cold meadow population had lower spectrum reflectance but higher melanin contents than light counterparts from the warm dune population. Additionally, the colorations of both dark and light lizards facilitated the camouflage and thermoregulation in their respective microhabitat simultaneously. More importantly, by genome resequencing analysis, we detected a novel mutation in Tyrp1 that underpinned this color adaptation. The allele frequencies at the site of SNP 459# in the gene of Tyrp1 are 22.22% G/C and 77.78% C/C in dark lizards and 100% G/G in light lizards. Model-predicted structure and catalytic activity showed that this mutation increased structure flexibility and catalytic activity in enzyme TYRP1, and thereby facilitated the generation of eumelanin in dark lizards. The function of the mutation in Tyrp1 was further verified by more melanin contents and darker coloration detected in the zebrafish injected with the genotype of Tyrp1 from dark lizards. Therefore, our study demonstrates that a novel mutation of a major melanin-generating gene underpins skin color variation co-selected by camouflage and thermoregulation in a lizard. The resulting strong selection may reinforce adaptive genetic divergence and enable the persistence of adjacent populations with distinct body coloration.
英文关键词color polymorphism; ecological adaptation; camouflage; thermal melanism hypothesis; melanin; reptile
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号WOS:001155261500001
来源期刊MOLECULAR BIOLOGY AND EVOLUTION
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/301686
作者单位Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ocean University of China; Hebei Normal University
推荐引用方式
GB/T 7714
Sun, Bao-Jun,Li, Wei-Ming,Lv, Peng,et al. Genetically Encoded Lizard Color Divergence for Camouflage and Thermoregulation[J],2024,41(2).
APA Sun, Bao-Jun.,Li, Wei-Ming.,Lv, Peng.,Wen, Guan-Nan.,Wu, Dan-Yang.,...&Du, Wei-Guo.(2024).Genetically Encoded Lizard Color Divergence for Camouflage and Thermoregulation.MOLECULAR BIOLOGY AND EVOLUTION,41(2).
MLA Sun, Bao-Jun,et al."Genetically Encoded Lizard Color Divergence for Camouflage and Thermoregulation".MOLECULAR BIOLOGY AND EVOLUTION 41.2(2024).
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