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| DOI | 10.1007/s00484-024-02672-y |
| Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle | |
| 发表日期 | 2024 |
| ISSN | 0020-7128 |
| EISSN | 1432-1254 |
| 英文摘要 | Animal geneticists and breeders have the impending challenge of enhancing the resilience of Indian livestock to heat stress through better selection strategies. Climate change's impact on livestock is more intense in tropical countries like India where dairy cattle crossbreeds are more sensitive to heat stress. The main reason for this study was to find the missing relative changes in transcript levels in thermo-neutral and heat stress conditions in crossbred cattle through whole-transcriptome analysis of RNA-Seq data. Differentially expressed genes (DEGs) identified based on the minimum log twofold change value and false discovery rate 0.05 revealed 468 up-regulated genes and 2273 down-regulated significant genes. Functional annotation and pathway analysis of these significant DEGs were compared based on Gene Ontology (Biological process), Kyoto Encyclopedia of Genes and Genome (KEGG), and Reactome pathways using g: Profiler, ShinyGO v0.76, and iDEP.951 web tools. On finding network visualization, the most over-represented and correlated pathways were neuronal and sensory organ development, calcium signalling pathway, Mitogen-activated protein kinase (MAPK) and Smad signalling pathway, Ras-proximate-1, or Ras-related protein 1 (Rap 1) signalling pathway, apoptosis, and oxidative stress. Similarly, down-regulated genes were most expressed in mRNA processing, immune system, B-cell receptor signalling pathway, Nucleotide oligomerization domain (NOD)-like receptors (NLRs) signalling pathway and nonsense-mediated decay (NMD) pathway. The heat stress-responsive genes identified in this study will facilitate our understanding of the molecular basis for climate resilience and heat tolerance in Indian dairy crossbreeds. |
| 英文关键词 | Transcriptome; Karan Fries; mRNA processing; Oxidative stress; MAPK and Smad signalling pathway |
| 语种 | 英语 |
| WOS研究方向 | Biophysics ; Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences ; Physiology |
| WOS类目 | Biophysics ; Environmental Sciences ; Meteorology & Atmospheric Sciences ; Physiology |
| WOS记录号 | WOS:001216016200001 |
| 来源期刊 | INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/301418 |
| 作者单位 | Indian Council of Agricultural Research (ICAR); ICAR - National Dairy Research Institute |
| 推荐引用方式 GB/T 7714 | . Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle[J],2024. |
| APA | (2024).Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle.INTERNATIONAL JOURNAL OF BIOMETEOROLOGY. |
| MLA | "Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle".INTERNATIONAL JOURNAL OF BIOMETEOROLOGY (2024). |
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