气候变化领域集成服务门户(CCPortal): Climate warming promotes collateral antibiotic resistance development in cyanobacteria

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DOI	10.1016/j.watres.2024.121642
	Climate warming promotes collateral antibiotic resistance development in cyanobacteria
	Wang, Zhiyuan; Chen, Qiuwen; Zhang, Jianyun; Xu, Huacheng; Miao, Lingzhan; Zhang, Tao; Liu, Dongsheng; Zhu, Qiuheng; Yan, Hanlu; Yan, Dandan
发表日期	2024
ISSN	0043-1354
EISSN	1879-2448
起始页码	256
卷号	256
英文摘要	Both cyanobacterial blooms and antibiotic resistance have aggravated worldwide and posed a great threat to public health in recent years. As a significant source and reservoir of water environmental resistome, cyanobacteria exhibit confusing discrepancy between their reduced susceptibility and their chronic exposure to antibiotic mixtures at sub-inhibitory concentrations. How the increasing temperature affects the adaptive evolution of cyanobacteria-associated antibiotic resistance in response to low-level antibiotic combinations under climate change remains unclear. Here we profiled the antibiotic interaction and collateral susceptibility networks among 33 commonly detected antibiotics in 600 cyanobacterial strains isolated from 50 sites across four eutrophicated lakes in China. Cyanobacteria-associated antibiotic resistance level was found positively correlated to antibiotic heterogeneity across all sites. Among 528 antibiotic combinations, antagonism was observed for 62 % interactions and highly conserved within cyanobacterial species. Collateral resistance was detected in 78.5 % of pairwise antibiotic interaction, leading to a widened or shifted upwards mutant selection window for increased opportunity of acquiring second-step mutations. We quantified the interactive promoting effect of collateral resistance and increasing temperature on the evolution of both phenotypic and genotypic cyanobacteria-associated resistance under chronic exposure to environmental level of antibiotic combinations. With temperature increasing from 16 degrees C to 36 degrees C, the evolvability index and genotypic resistance level increased by 1.25 - 2.5 folds and 3 - 295 folds in the collateral-resistance-informed lineages, respectively. Emergence of resistance mutation pioneered by tolerance, which was jointly driven by mutation rate and persister fraction, was found to be accelerated by increased temperature and antibiotic switching rate. Our findings provided mechanic insights into the boosting effect of climate warming on the emergence and development of cyanobacteriaassociated resistance against collateral antibiotic phenotypes.
英文关键词	Temperature; Cyanobacteria-associated antibiotic resistance; Antibiotic interaction; Collateral resistance; Resistance development
语种	英语
WOS研究方向	Engineering ; Environmental Sciences & Ecology ; Water Resources
WOS类目	Engineering, Environmental ; Environmental Sciences ; Water Resources
WOS记录号	WOS:001233497900001
来源期刊	WATER RESEARCH
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/301310
作者单位	Nanjing Hydraulic Research Institute; Nanjing Hydraulic Research Institute; Hohai University; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; Hohai University
推荐引用方式 GB/T 7714	Wang, Zhiyuan,Chen, Qiuwen,Zhang, Jianyun,et al. Climate warming promotes collateral antibiotic resistance development in cyanobacteria[J],2024,256.
APA	Wang, Zhiyuan.,Chen, Qiuwen.,Zhang, Jianyun.,Xu, Huacheng.,Miao, Lingzhan.,...&Yan, Dandan.(2024).Climate warming promotes collateral antibiotic resistance development in cyanobacteria.WATER RESEARCH,256.
MLA	Wang, Zhiyuan,et al."Climate warming promotes collateral antibiotic resistance development in cyanobacteria".WATER RESEARCH 256(2024).