气候变化领域集成服务门户(CCPortal): Acute exposure to pollen and airway inflammation in adolescents

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DOI	10.1002/ppul.26908
	Acute exposure to pollen and airway inflammation in adolescents
	Nassikas, Nicholas J.; Luttmann-Gibson, Heike; Rifas-Shiman, Sheryl L.; Oken, Emily; Gold, Diane R.; Rice, Mary B.
发表日期	2024
ISSN	8755-6863
EISSN	1099-0496
英文摘要	Introduction: Pollen exposure is known to exacerbate allergic asthma and allergic rhinitis symptoms, yet few studies have investigated if exposure to pollen affects lung function or airway inflammation in healthy children. Methods: We evaluated the extent to which higher pollen exposure was associated with differences in airway inflammation and lung function among 490 early adolescent participants (mean age of 12.9 years) in Project Viva, a prebirth cohort based in Massachusetts. We obtained regional daily total pollen counts, including tree, grass, and weed pollen, from a Rotorod pollen counter. We evaluated associations of 3- and 7-day moving averages of pollen with fractional exhaled nitric oxide (FeNO) and lung function using linear regression models and evaluated the linearity of associations with penalized splines. We tested if associations of pollen with FeNO and lung function were modified by current asthma diagnosis, history of allergic rhinitis, aeroallergen sensitivity, temperature, precipitation, and air pollution. Results: Three- and 7-day median pollen concentrations were 19.0 grains/m3 (IQR: 73.4) and 20.9 grains/m3 (IQR: 89.7). In main models, higher concentrations of total pollen over the preceding 3 and 7 days were associated with a 4.6% (95% CI: 0.1,9.2) and 7.4% (95% CI: 0.9,14.3) higher FeNO per IQR of pollen, respectively. We did not find associations of pollen with lung function in main models. Asthma, allergic rhinitis, precipitation, and air pollution (nitrogen dioxide and ozone) modified associations of pollen with lung function (Pinteraction < 0.1), while temperature, sex, and aeroallergen sensitization did not. Conclusion: Short-term exposure to pollen was associated with higher FeNO in early adolescents, even in the absence of allergic sensitization and asthma.
英文关键词	aeroallergen; asthma; climate change; exhaled nitric oxide; lung function
语种	英语
WOS研究方向	Pediatrics ; Respiratory System
WOS类目	Pediatrics ; Respiratory System
WOS记录号	WOS:001162048300001
来源期刊	PEDIATRIC PULMONOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/301185
作者单位	Harvard University; Beth Israel Deaconess Medical Center; Harvard University; Harvard T.H. Chan School of Public Health; Harvard Pilgrim Health Care; Harvard University; Harvard Medical School; Harvard University; Brigham & Women's Hospital; Harvard Medical School
推荐引用方式 GB/T 7714	Nassikas, Nicholas J.,Luttmann-Gibson, Heike,Rifas-Shiman, Sheryl L.,et al. Acute exposure to pollen and airway inflammation in adolescents[J],2024.
APA	Nassikas, Nicholas J.,Luttmann-Gibson, Heike,Rifas-Shiman, Sheryl L.,Oken, Emily,Gold, Diane R.,&Rice, Mary B..(2024).Acute exposure to pollen and airway inflammation in adolescents.PEDIATRIC PULMONOLOGY.
MLA	Nassikas, Nicholas J.,et al."Acute exposure to pollen and airway inflammation in adolescents".PEDIATRIC PULMONOLOGY (2024).