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| DOI | 10.1186/s12864-024-09987-5 |
| Chromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral) | |
| 发表日期 | 2024 |
| ISSN | 1471-2164 |
| 起始页码 | 25 |
| 结束页码 | 1 |
| 卷号 | 25期号:1 |
| 英文摘要 | Background: Gorals Naemorhedus resemble both goats and antelopes, which prompts much debate about the intragenus species delimitation and phylogenetic status of the genus Naemorhedus within the subfamily Caprinae. Their evolution is believed to be linked to the uplift of the Qinghai-Tibet Plateau (QTP). To better understand its phylogenetics, the genetic information is worth being resolved. Results: Based on a sample from the eastern margin of QTP, we constructed the first reference genome for Himalayan goral Naemorhedus goral, using PacBio long-read sequencing and Hi-C technology. The 2.59 Gb assembled genome had a contig N50 of 3.70 Mb and scaffold N50 of 106.66 Mb, which anchored onto 28 pseudo chromosomes. A total of 20,145 protein-coding genes were predicted in the assembled genome, of which 99.93% were functionally annotated. Phylogenetically, the goral was closely related to muskox on the mitochondrial genome level and nested into the takin-muskox clade on the genome tree, rather than other so-called goat-antelopes. The cladogenetic event among muskox, takin and goral occurred sequentially during the late Miocene (similar to 11 - 5 Mya), when the QTP experienced a third dramatic uplift with consequent profound changes in climate and environment. Several chromosome fusions and translocations were observed between goral and takin/muskox. The expanded gene families in the goral genome were mainly related to the metabolism of drugs and diseases, so as the positive selected genes. The Ne of goral continued to decrease since similar to 1 Mya during the Pleistocene with active glaciations. Conclusion: The high-quality goral genome provides insights into the evolution and valuable information for the conservation of this threatened group. |
| 英文关键词 | Chromosome-level genome; De novo assembly; Goral; Phylogenetics; Conservation |
| 语种 | 英语 |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS记录号 | WOS:001155095200007 |
| 来源期刊 | BMC GENOMICS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/301134 |
| 作者单位 | Zhengzhou University; Qinghai Normal University; Northwestern Polytechnical University; Xi'an Jiaotong University |
| 推荐引用方式 GB/T 7714 | . Chromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral)[J],2024,25(1). |
| APA | (2024).Chromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral).BMC GENOMICS,25(1). |
| MLA | "Chromosome-level genome provides insight into the evolution and conservation of the threatened goral (Naemorhedus goral)".BMC GENOMICS 25.1(2024). |
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