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| DOI | 10.1073/pnas.2317461121 |
| A large- effect fitness trade- off across environments is explained by a single mutation affecting cold acclimation | |
| 发表日期 | 2024 |
| ISSN | 0027-8424 |
| EISSN | 1091-6490 |
| 起始页码 | 121 |
| 结束页码 | 6 |
| 卷号 | 121期号:6 |
| 英文摘要 | Identifying the genetic basis of local adaptation and fitness trade - offs across environments is a central goal of evolutionary biology. Cold acclimation is an adaptive plastic response for surviving seasonal freezing, and costs of acclimation may be a general mechanism for fitness trade - offs across environments in temperate zone species. Starting with locally adapted ecotypes of Arabidopsis thaliana from Italy and Sweden, we examined the fitness consequences of a naturally occurring functional polymorphism in CBF2. This gene encodes a transcription factor that is a major regulator of cold- acclimated freezing tolerance and resides within a locus responsible for a genetic trade - off for long - term mean fitness. We estimated the consequences of alternate genotypes of CBF2 on 5- y mean fitness and fitness components at the native field sites by comparing near- isogenic lines with alternate genotypes of CBF2 to their genetic background ecotypes. The effects of CBF2 were validated at the nucleotide level using gene- edited lines in the native genetic backgrounds grown in simulated parental environments. The foreign CBF2 genotype in the local genetic background reduced long - term mean fitness in Sweden by more than 10%, primarily via effects on survival. In Italy, fitness was reduced by more than 20%, primarily via effects on fecundity. At both sites, the effects were temporally variable and much stronger in some years. The gene- edited lines confirmed that CBF2 encodes the causal variant underlying this genetic trade - off. Additionally, we demonstrated a substantial fitness cost of cold acclimation, which has broad implications for potential maladaptive responses to climate change. |
| 英文关键词 | antagonistic pleiotropy; cold acclimation; genetic trade; local adaptation |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001169138400008 |
| 来源期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/300932 |
| 作者单位 | Purdue University System; Purdue University; Purdue University System; Purdue University; Uppsala University; Purdue University System; Purdue University; Colorado State University; State University System of Florida; University of Florida; University of Kansas; University of Kansas; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI) |
| 推荐引用方式 GB/T 7714 | . A large- effect fitness trade- off across environments is explained by a single mutation affecting cold acclimation[J],2024,121(6). |
| APA | (2024).A large- effect fitness trade- off across environments is explained by a single mutation affecting cold acclimation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,121(6). |
| MLA | "A large- effect fitness trade- off across environments is explained by a single mutation affecting cold acclimation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121.6(2024). |
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