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| DOI | 10.1080/08958378.2024.2354398 |
| A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures | |
| 发表日期 | 2024 |
| ISSN | 0895-8378 |
| EISSN | 1091-7691 |
| 英文摘要 | Due to climate change, wildfires have increased in intensity and duration. While wildfires threaten lives directly, the smoke has more far-reaching adverse health impacts. During an extreme 2017 wildfire event, residents of Seeley Lake, Montana were exposed to unusually high levels of wood smoke (WS) causing sustained effects on lung function (decreased FEV1/FVC). Objective: The present study utilized an animal model of WS exposure to research cellular and molecular mechanisms of the resulting health effects. Methods: Mice were exposed to inhaled WS utilizing locally harvested wood to recapitulate community exposures. WS was generated at a rate resulting in a 5 mg/m3 PM2.5 exposure for five days. Results: This exposure resulted in a similar 0.28 mg/m2 particle deposition (lung surface area) in mice that was calculated for human exposure. As with the community observations, there was a significant effect on lung function, increased resistance, and decreased compliance, that was more pronounced in males at an extended (2 months) timepoint and males were more affected than females: ex vivo assays illustrated changes to alveolar macrophage functions (increased TNF alpha secretion and decreased efferocytosis). Female mice had significantly elevated IL-33 levels in lungs, however, pretreatment of male mice with IL-33 resulted in an abrogation of the observed WS effects, suggesting a dose-dependent role of IL-33. Additionally, there were greater immunotoxic effects in male mice. Discussion: These findings replicated the outcomes in humans and suggest that IL-33 is involved in a mechanism of the adverse effects of WS exposures that inform on potential sex differences. |
| 英文关键词 | Wood smoke; inflammation; mouse; particles; macrophage; sex differences; acute; extended effects; cytokines |
| 语种 | 英语 |
| WOS研究方向 | Toxicology |
| WOS类目 | Toxicology |
| WOS记录号 | WOS:001227869900001 |
| 来源期刊 | INHALATION TOXICOLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/299974 |
| 作者单位 | University of Montana System; University of Montana |
| 推荐引用方式 GB/T 7714 | . A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures[J],2024. |
| APA | (2024).A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures.INHALATION TOXICOLOGY. |
| MLA | "A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures".INHALATION TOXICOLOGY (2024). |
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