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| DOI | 10.1016/j.jep.2024.117933 |
| The whitening effect of cuscutin responsible for traditional use of Bergenia purpurascens | |
| 发表日期 | 2024 |
| ISSN | 0378-8741 |
| EISSN | 1872-7573 |
| 起始页码 | 326 |
| 卷号 | 326 |
| 英文摘要 | Ethnopharmacological relevance: The roots and rhizomes of Bergenia purpurascens (Hook. f. et Thomson) Engl., was used as a sunscreen to protect against ultraviolet rays in Tibet of China historically, but its skin whitening constituents and pharmacological effects of this plant remained unknown. Aim of the study: To investigate the anti-melanogenesis effect of B. purpurascens in vitro and in vivo, and then explore the preliminary mechanism. Materials and methods: An ultraviolet B (UVB)-induced skin injury model of mice was used to verify the ameliorative effect of B. purpurascens extract (BPE) on ultraviolet damage. Then, alpha-melanocyte stimulating hormone (alpha-MSH)-induced murine melanoma cell line (B16F10) melanin generation model was further adopted to approval the effects of BPE and its bioactive compound, cuscutin, in vitro. Moreover, alpha-MSH stimulated melanogenesis model in zebrafish was employed to confirm the anti-pigmentation effect of cuscutin. Then, proteins expressions associated with melanin production were observed using western blotting assay to explore preliminary mechanism. Results: BPE inhibited UVB-induced mice injury and restored skin barrier function observably in vivo. BPE and cuscutin suppressed the overproduction of melanin in alpha-MSH induced B16F10 significantly, in which cuscutin exhibited better effect than well-known whitening agent alpha-arbutin at same 10 mu g/mL concentration. Moreover, the pigmentation of zebrafish embryo was decreased by cuscutin. Finally, cuscutin showed significant downregulation of expressions of tyrosinase (TYR) and tyrosinase related protein-1 (TRP-1), TRP-2 and microphthalmia-associated transcription factor (MITF) in the melanogenic signaling pathway. Conclusion: B. purpurascens extract and its major bioactive constituent, cuscutin, showed potent antimelanogenesis and skin-whitening effect by targeting TYR and TRP-2 proteins for the first time, which supported its traditional use. |
| 英文关键词 | Bergenia purpurascens; Cuscutin; Whitening; Anti-melanogenesis |
| 语种 | 英语 |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:001203022600001 |
| 来源期刊 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/299077 |
| 作者单位 | Yunnan University; Chinese Academy of Sciences; Kunming Institute of Botany, CAS |
| 推荐引用方式 GB/T 7714 | . The whitening effect of cuscutin responsible for traditional use of Bergenia purpurascens[J],2024,326. |
| APA | (2024).The whitening effect of cuscutin responsible for traditional use of Bergenia purpurascens.JOURNAL OF ETHNOPHARMACOLOGY,326. |
| MLA | "The whitening effect of cuscutin responsible for traditional use of Bergenia purpurascens".JOURNAL OF ETHNOPHARMACOLOGY 326(2024). |
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