气候变化领域集成服务门户(CCPortal): Whole-genome resequencing of major populations revealed domestication-related genes in yaks

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DOI	10.1186/s12864-024-09993-7
	Whole-genome resequencing of major populations revealed domestication-related genes in yaks
	Peng, Wei; Fu, Changqi; Shu, Shi; Wang, Guowen; Wang, Hui; Yue, Binglin; Zhang, Ming; Liu, Xinrui; Liu, Yaxin; Zhang, Jun; Zhong, Jincheng; Wang, Jiabo
发表日期	2024
ISSN	1471-2164
起始页码	25
结束页码	1
卷号	25 期号:1
英文摘要	BackgroundThe yak is a symbol of the Qinghai-Tibet Plateau and provides important basic resources for human life on the plateau. Domestic yaks have been subjected to strong artificial selection and environmental pressures over the long-term. Understanding the molecular mechanisms of phenotypic differences in yak populations can reveal key functional genes involved in the domestication process and improve genetic breeding.Material and methodHere, we re-sequenced 80 yaks (Maiwa, Yushu, and Huanhu populations) to identify single-nucleotide polymorphisms (SNPs) as genetic variants. After filtering and quality control, remaining SNPs were kept to identify the genome-wide regions of selective sweeps associated with domestic traits. The four methods (pi, XPEHH, iHS, and XP-nSL) were used to detect the population genetic separation.ResultsBy comparing the differences in the population stratification, linkage disequilibrium decay rate, and characteristic selective sweep signals, we identified 203 putative selective regions of domestic traits, 45 of which were mapped to 27 known genes. They were clustered into 4 major GO biological process terms. All known genes were associated with seven major domestication traits, such as dwarfism (ANKRD28), milk (HECW1, HECW2, and OSBPL2), meat (SPATA5 and GRHL2), fertility (BTBD11 and ARFIP1), adaptation (NCKAP5, ANTXR1, LAMA5, OSBPL2, AOC2, and RYR2), growth (GRHL2, GRID2, SMARCAL1, and EPHB2), and the immune system (INPP5D and ADCYAP1R1).ConclusionsWe provided there is an obvious genetic different among domestic progress in these three yak populations. Our findings improve the understanding of the major genetic switches and domestic processes among yak populations.
英文关键词	Yaks; Population stratification; Selective sweep; Domestication
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:001144648500004
来源期刊	BMC GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/299046
作者单位	Qinghai University; Southwest Minzu University; Southwest Minzu University
推荐引用方式 GB/T 7714	Peng, Wei,Fu, Changqi,Shu, Shi,et al. Whole-genome resequencing of major populations revealed domestication-related genes in yaks[J],2024,25(1).
APA	Peng, Wei.,Fu, Changqi.,Shu, Shi.,Wang, Guowen.,Wang, Hui.,...&Wang, Jiabo.(2024).Whole-genome resequencing of major populations revealed domestication-related genes in yaks.BMC GENOMICS,25(1).
MLA	Peng, Wei,et al."Whole-genome resequencing of major populations revealed domestication-related genes in yaks".BMC GENOMICS 25.1(2024).