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DOI | 10.1038/s41559-023-02275-7 |
Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors | |
An, Xuan; Mao, Leyan; Wang, Yinjia; Xu, Qinqin; Liu, Xi; Zhang, Shangzhe; Qiao, Zhenglei; Li, Bowen; Li, Fang; Kuang, Zhuoran; Wan, Na; Liang, Xiaolong; Duan, Qijiao; Feng, Zhilong; Yang, Xiaojie; Liu, Sanyuan; Nevo, Eviatar; Liu, Jianquan; Storz, Jay F.; Li, Kexin | |
发表日期 | 2024 |
ISSN | 2397-334X |
英文摘要 | Zokors, an Asiatic group of subterranean rodents, originated in lowlands and colonized high-elevational zones following the uplift of the Qinghai-Tibet plateau about 3.6 million years ago. Zokors live at high elevation in subterranean burrows and experience hypobaric hypoxia, including both hypoxia (low oxygen concentration) and hypercapnia (elevated partial pressure of CO2). Here we report a genomic analysis of six zokor species (genus Eospalax) with different elevational ranges to identify structural variants (deletions and inversions) that may have contributed to high-elevation adaptation. Based on an assembly of a chromosome-level genome of the high-elevation species, Eospalax baileyi, we identified 18 large inversions that distinguished this species from congeners native to lower elevations. Small-scale structural variants in the introns of EGLN1, HIF1A, HSF1 and SFTPD of E. baileyi were associated with the upregulated expression of those genes. A rearrangement on chromosome 1 was associated with altered chromatin accessibility, leading to modified gene expression profiles of key genes involved in the physiological response to hypoxia. Multigene families that underwent copy-number expansions in E. baileyi were enriched for autophagy, HIF1 signalling and immune response. E. baileyi show a significantly larger lung mass than those of other Eospalax species. These findings highlight the key role of structural variants underlying hypoxia adaptation of high-elevation species in Eospalax. Comparative analysis of whole-genome sequencing of six zokor species that live at different altitudes show the contribution of deletions and inversions to adaptation to high altitude in these subterranean rodents. |
语种 | 英语 |
WOS研究方向 | Environmental Sciences & Ecology ; Evolutionary Biology |
WOS类目 | Ecology ; Evolutionary Biology |
WOS记录号 | WOS:001138889600002 |
来源期刊 | NATURE ECOLOGY & EVOLUTION (IF:10.965[JCR-2018],10.969[5-Year]) |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/299038 |
作者单位 | Lanzhou University; Mudanjiang Normal University; University of Haifa; University of Nebraska System; University of Nebraska Lincoln |
推荐引用方式 GB/T 7714 | An, Xuan,Mao, Leyan,Wang, Yinjia,et al. Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors[J],2024. |
APA | An, Xuan.,Mao, Leyan.,Wang, Yinjia.,Xu, Qinqin.,Liu, Xi.,...&Li, Kexin.(2024).Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors.NATURE ECOLOGY & EVOLUTION. |
MLA | An, Xuan,et al."Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors".NATURE ECOLOGY & EVOLUTION (2024). |
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