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DOI10.1038/s41559-023-02275-7
Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors
An, Xuan; Mao, Leyan; Wang, Yinjia; Xu, Qinqin; Liu, Xi; Zhang, Shangzhe; Qiao, Zhenglei; Li, Bowen; Li, Fang; Kuang, Zhuoran; Wan, Na; Liang, Xiaolong; Duan, Qijiao; Feng, Zhilong; Yang, Xiaojie; Liu, Sanyuan; Nevo, Eviatar; Liu, Jianquan; Storz, Jay F.; Li, Kexin
发表日期2024
ISSN2397-334X
英文摘要Zokors, an Asiatic group of subterranean rodents, originated in lowlands and colonized high-elevational zones following the uplift of the Qinghai-Tibet plateau about 3.6 million years ago. Zokors live at high elevation in subterranean burrows and experience hypobaric hypoxia, including both hypoxia (low oxygen concentration) and hypercapnia (elevated partial pressure of CO2). Here we report a genomic analysis of six zokor species (genus Eospalax) with different elevational ranges to identify structural variants (deletions and inversions) that may have contributed to high-elevation adaptation. Based on an assembly of a chromosome-level genome of the high-elevation species, Eospalax baileyi, we identified 18 large inversions that distinguished this species from congeners native to lower elevations. Small-scale structural variants in the introns of EGLN1, HIF1A, HSF1 and SFTPD of E. baileyi were associated with the upregulated expression of those genes. A rearrangement on chromosome 1 was associated with altered chromatin accessibility, leading to modified gene expression profiles of key genes involved in the physiological response to hypoxia. Multigene families that underwent copy-number expansions in E. baileyi were enriched for autophagy, HIF1 signalling and immune response. E. baileyi show a significantly larger lung mass than those of other Eospalax species. These findings highlight the key role of structural variants underlying hypoxia adaptation of high-elevation species in Eospalax. Comparative analysis of whole-genome sequencing of six zokor species that live at different altitudes show the contribution of deletions and inversions to adaptation to high altitude in these subterranean rodents.
语种英语
WOS研究方向Environmental Sciences & Ecology ; Evolutionary Biology
WOS类目Ecology ; Evolutionary Biology
WOS记录号WOS:001138889600002
来源期刊NATURE ECOLOGY & EVOLUTION (IF:10.965[JCR-2018],10.969[5-Year])
文献类型期刊论文
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/299038
作者单位Lanzhou University; Mudanjiang Normal University; University of Haifa; University of Nebraska System; University of Nebraska Lincoln
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GB/T 7714
An, Xuan,Mao, Leyan,Wang, Yinjia,et al. Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors[J],2024.
APA An, Xuan.,Mao, Leyan.,Wang, Yinjia.,Xu, Qinqin.,Liu, Xi.,...&Li, Kexin.(2024).Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors.NATURE ECOLOGY & EVOLUTION.
MLA An, Xuan,et al."Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors".NATURE ECOLOGY & EVOLUTION (2024).
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