气候变化领域集成服务门户(CCPortal): Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii

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DOI	10.1016/j.fsi.2024.109516
	Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii
	Sousa, Carmen S. V.; Peng, Maoxiao; Guerreiro, Pedro M.; Cardoso, Joao C. R.; Chen, Liangbiao; Canario, Adelino V. M.; Power, Deborah M.
发表日期	2024
ISSN	1050-4648
EISSN	1095-9947
起始页码	148
卷号	148
英文摘要	The genome evolution of Antarctic notothenioids has been modulated by their extreme environment over millennia and more recently by human -caused constraints such as overfishing and climate change. Here we investigated the characteristics of the immune system in Notothenia rossii and how it responds to 8 h immersion in viral (Poly I:C, polyinosinic: polycytidylic acid) and bacterial (LPS, lipopolysaccharide) proxies. Blood plasma antiprotease activity and haematocrit were reduced in Poly I:C-treated fish only, while plasma protein, lysozyme activity and cortisol were unchanged with both treatments. The skin and duodenum transcriptomes responded strongly to the treatments, unlike the liver and spleen which had a mild response. Furthermore, the skin transcriptome responded most to the bacterial proxy (cell adhesion, metabolism and immune response processes) and the duodenum (metabolism, response to stress, regulation of intracellular signal transduction, and immune system responses) to the viral proxy. The differential tissue response to the two proxy challenges is indicative of immune specialisation of the duodenum and the skin towards pathogens. NOD -like and C -type lectin receptors may be central in recognising LPS and Poly I:C. Other antimicrobial compounds such as iron and seleniumrelated genes are essential defence mechanisms to protect the host from sepsis. In conclusion, our study revealed a specific response of two immune barrier tissue, the skin and duodenum, in Notothenia rossii when exposed to pathogen proxies by immersion, and this may represent an adaptation to pathogen infective strategies.
英文关键词	Nototheniidae; Endotoxin; Immune system; Transcriptome; Viral stimuli
语种	英语
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:001206008200001
来源期刊	FISH & SHELLFISH IMMUNOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/298991
作者单位	Universidade do Algarve; Shanghai Ocean University; Shanghai Ocean University; Universidade do Algarve
推荐引用方式 GB/T 7714	Sousa, Carmen S. V.,Peng, Maoxiao,Guerreiro, Pedro M.,et al. Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii[J],2024,148.
APA	Sousa, Carmen S. V..,Peng, Maoxiao.,Guerreiro, Pedro M..,Cardoso, Joao C. R..,Chen, Liangbiao.,...&Power, Deborah M..(2024).Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii.FISH & SHELLFISH IMMUNOLOGY,148.
MLA	Sousa, Carmen S. V.,et al."Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii".FISH & SHELLFISH IMMUNOLOGY 148(2024).