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| DOI | 10.1016/j.fsi.2024.109516 |
| Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii | |
| 发表日期 | 2024 |
| ISSN | 1050-4648 |
| EISSN | 1095-9947 |
| 起始页码 | 148 |
| 卷号 | 148 |
| 英文摘要 | The genome evolution of Antarctic notothenioids has been modulated by their extreme environment over millennia and more recently by human -caused constraints such as overfishing and climate change. Here we investigated the characteristics of the immune system in Notothenia rossii and how it responds to 8 h immersion in viral (Poly I:C, polyinosinic: polycytidylic acid) and bacterial (LPS, lipopolysaccharide) proxies. Blood plasma antiprotease activity and haematocrit were reduced in Poly I:C-treated fish only, while plasma protein, lysozyme activity and cortisol were unchanged with both treatments. The skin and duodenum transcriptomes responded strongly to the treatments, unlike the liver and spleen which had a mild response. Furthermore, the skin transcriptome responded most to the bacterial proxy (cell adhesion, metabolism and immune response processes) and the duodenum (metabolism, response to stress, regulation of intracellular signal transduction, and immune system responses) to the viral proxy. The differential tissue response to the two proxy challenges is indicative of immune specialisation of the duodenum and the skin towards pathogens. NOD -like and C -type lectin receptors may be central in recognising LPS and Poly I:C. Other antimicrobial compounds such as iron and seleniumrelated genes are essential defence mechanisms to protect the host from sepsis. In conclusion, our study revealed a specific response of two immune barrier tissue, the skin and duodenum, in Notothenia rossii when exposed to pathogen proxies by immersion, and this may represent an adaptation to pathogen infective strategies. |
| 英文关键词 | Nototheniidae; Endotoxin; Immune system; Transcriptome; Viral stimuli |
| 语种 | 英语 |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS类目 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS记录号 | WOS:001206008200001 |
| 来源期刊 | FISH & SHELLFISH IMMUNOLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/298990 |
| 作者单位 | Universidade do Algarve; Shanghai Ocean University; Shanghai Ocean University; Universidade do Algarve |
| 推荐引用方式 GB/T 7714 | . Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii[J],2024,148. |
| APA | (2024).Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii.FISH & SHELLFISH IMMUNOLOGY,148. |
| MLA | "Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii".FISH & SHELLFISH IMMUNOLOGY 148(2024). |
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